肿瘤坏死因子-α(TNF-α)是最主要的促炎症细胞因子之一,主要是由激活的单核/巨噬细胞分泌,在炎症、免疫调节反应、细胞生长、细胞凋亡中起重要作用。左心室重构可导致心肌病进行性发展,甚至引起恶性心律失常、心力衰竭及心源性猝死的发生,其进展过程中与肿瘤坏死因子-α(TNF-α)密切相关,肿瘤坏死因子-α(TNF-α)的研究可帮助临床医师及早识别无临床症状患者心室重构的发生,且通过抗肿瘤坏死因子-α(TNF-α)的治疗对延缓心室重构及改善患者预后发挥着重要作用。本文就肿瘤坏死因子- α(TNF-α)与左心室重构关系的最新研究进展进行综述。
Tumor necrosis factor alpha (TNF-alpha) is one of the most potent pro-inflammatory cytokines, which is mainly secreted by activated monocytes/macrophages and plays an important role in in-flammation, immunoregulation, cell growth and apoptosis. Left ventricular remodeling can lead to progressive cardiomyopathy, and even cause malignant arrhythmia, heart failure and sudden car-diac death; TNF-alpha is closely related to the progress of left ventricular remodeling. The research of TNF-alpha may help clinical physicians to identify patients with no clinical evidence of ventricular remodeling, and anti-TNF may play a significant role in delaying the progress of ventricular remodeling and improving the prognosis of patients. This paper makes a review of the recent research progress on the correlation between TNF-alpha and left ventricular remodeling.
农美虹,黄学成. 肿瘤坏死因子-α与左心室重构关系的研究进展Progressive Study of Correlation between Tumor Necrosis Factor Alpha and Left Ventricular Remodeling[J]. 临床医学进展, 2017, 07(01): 6-10. http://dx.doi.org/10.12677/ACM.2017.71002
参考文献 (References)References陈红, 连榅林, 陈力. 肿瘤坏死因子和心脏疾病[J]. 中国药理学通报, 2001, 17(4): 380-382.李强. 肿瘤坏死因子-α与慢性心力衰竭[J]. 中国医刊, 2009, 44(1): 58-59.Bozkurt, B., Kribbs, S.B., Clubb, F.J., et al. (1998) Pathophysiologically Relevant Concentration of Tumor Necrosis Factor-α Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats. Circulation, 97, 1382-1391.
<br>https://doi.org/10.1161/01.CIR.97.14.1382Torre-Amione, G., Kapadia, S., Lee, J., Bies, R.D., Lebovitz, R. and Mann, D.L. (1995) Expression and Functional Significance of Tumor Necrosis Factor Receptors in Human Myocardium. Circulation, 92, 1487-1493.
<br>https://doi.org/10.1161/01.CIR.92.6.1487Stamm, C., Friehs, I., Cowan, D.B., et al. (2001) Inhibition of Tumor Necrosis Factor-Alpha Improves Postischemic Recovery of Hypertrophied Hearts. Circulation, 104, I350-1355. <br>https://doi.org/10.1161/hc37t1.094851Satoh, M., Nakamura, M., Tamura, G., et al. (1997) Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-Alpha in Myocardium in Human Dilated Cardiomyopathy. Journal of the American College of Cardiology, 29, 716-724.
<br>https://doi.org/10.1016/S0735-1097(96)00567-0龚玮琦, 江华, 陈巍, 刘玥. 左心室射血分数正常的慢性心力衰竭患者血清脂联素, B型脑钠肽及肿瘤坏死因子- α的相关性研究[J]. 中国全科医学, 2013(14): 1221-1223.李代挑, 解少强, 邱正强. 肿瘤坏死因子-α在风心病中的表达及其与心功能关系的研究[J]. 陕西医学杂志, 2014(4): 403-405.刘娟, 景世宁. 扩张型心肌病TNF, IL-1和SIL-2R的检测及其意义[J]. 河南诊断与治疗杂志, 2002, 16(6): 423- 424.Winkles, J.A. (2008) The Tweak-Fn14 Cytokine-Receptor Axis: Discovery, Biology and Therapeutic Targeting. Nature Reviews Drug Discovery, 7, 411-425. <br>https://doi.org/10.1038/nrd2488张丽枫, 刘素云. 血浆脂联素和肿瘤坏死因子-α与充血性心力衰竭的相关性研究[J]. 心血管病学进展, 2008, 29(S1): 48-50.Kubota, T., McTiernan, C.F., Frye, C.S., et al. (1997) Dilated Cardiomyopathy in Transgenic Mice with Cardiac-Spe- cific Over Expression of Tumor Necrosis Factor-Alpha. Circulation Research, 81, 627-635.
<br>https://doi.org/10.1161/01.RES.81.4.627Yokoyama, T., Vaca, L., Rossen, R.D., Durante, W., Hazarika, P. and Mann, D.L. (1993) Cellular Basis for the Negative Inotropic Effects of Tumor Necrosis Factor-Alpha in the Adult Mammalian Heart. Journal of Clinical Investigation, 92, 2303-2312. <br>https://doi.org/10.1172/JCI116834Pagani, F.D., Baker, L.S., His, C., et al. (1992) Left Ventricular Systolic and Diastolic Dysfunction after Infusion of Tumor Necrosis Factor-Alpha in Conscious Dogs. Journal of Clinical Investigation, 90, 389-398.
<br>https://doi.org/10.1172/JCI115873杨天睿, 段靳岚. 心血管保护性因子与心血管疾病的关系[J]. 中国社区医师, 2016, 32(2): 10-11.Damman, P., Kempf, T., Windhausen, F., et al. (2014) Growth-Differentiation Factor 15 for Long-Term Prognos-tication in Patients with Non-ST-Elevation Acute Coronary Syndrome: An Invasive versus Conservative Treatment in Unstable Cor-onary Syndromes (ICTUS) Substudy. International Journal of Cardiology, 172, 356-363.
<br>https://doi.org/10.1016/j.ijcard.2014.01.025Epelman, S., Tang, W.H., Chen, S.Y., et al. (2008) Detection of Soluble An-giotensin-Converting Enzyme 2 in Heart Failure: Insights into the Endogenous Counter-Regulatory Pathway of the Ren-in-Angiotensin-Aldosterone System. Journal of the American College of Cardiology, 52, 750-754. <br>https://doi.org/10.1016/j.jacc.2008.02.088Ohtsuki, M., Morimoto, S., Izawa, H., et al. (2010) Angiotensin Converting Enzyme 2 Gene Expression Increased Compensatory for Left Ventricular Remodeling in Patients with End-Stage Heart Failure. In-ternational Journal of Cardiology, 145, 333-334. <br>https://doi.org/10.1016/j.ijcard.2009.11.057黄璟, 周毅. 肿瘤坏死因子-α及其抑制剂的研究进展[J]. 国际口腔医学杂志, 2015, 42(1): 63-68.杨帆, 杨秀荣. 肿瘤坏死因子与可溶性受体之间相互作用的动力学研究[J]. 分析化学, 2013, 41(5): 664-669.