肥胖是增长最快、最具挑战性的公共卫生问题之一,具有严重的医学、心理和情感后果。尽管有大量研究阐述了肥胖的有害影响但仍难以有效地激励肥胖人群改变生活方式或选择手术减肥。近年来有多项研究发现肥胖与男性性功能障碍有关,但机制仍缺乏综合性论述,且在减肥是否对肥胖性功能障碍患者的预后有帮助存在争议。本文综述了有关肥胖与性功能障碍之间联系的各种证据和机制以及减肥对男性性功能障碍预后的影响,旨在通过告知肥胖与性功能障碍的潜在负面影响激励肥胖人群减肥并为男性性功能障碍的预防与治疗提供思路。
Obesity is one of the fastest-growing and most challenging public health problems, with serious medical, psychological and emotional consequences. Despite numerous studies demonstrating the deleterious effects of obesity, it is difficult to effectively motivate obese people to change their lifestyle or choose surgery for weight loss. In recent years, a number of studies have found that obesity is associated with male sexual dysfunction, but there is still a lack of comprehensive dis-cussion on the mechanism, and there is controversy over whether weight loss can help the prog-nosis of obese sexual dysfunction patients. This paper reviews the evidence and mechanism of the association between obesity and sexual dysfunction and the effect of weight loss on the prognosis of male sexual dysfunction, aiming to motivate obese people to lose weight by informing the potential negative effects of obesity and sexual dysfunction and providing ideas for the prevention and treatment of male sexual dysfunction.
肥胖,性功能障碍,早泄,勃起功能障碍,减肥, Obesity Sexual Dysfunction Premature Ejaculation Erectile Dysfunction Lose Weight肥胖与男性性功能障碍
内皮细胞分泌许多活性物质,包括内皮源性收缩因子及内皮源性舒张因子,两种因子共同调节血流,以维持稳定充足的组织灌注。其中海绵窦内皮细胞分泌的 NO 是阴茎正常勃起最重要的神经介质,其由血管内皮细胞产生后,通过弥散方式进入平滑肌细胞,引起平滑肌松弛而诱发勃起 [24] 。因此,血管内皮既保证血管机能的正常,又可合成释放扩血管介质诱发勃起。当肥胖相关的代谢紊乱引起的内皮功能障碍时,常常会引起的NO减少、NO利用率降低从诱发勃起功能障碍。
徐姜南,张宇慧,裴昌松. 肥胖与男性性功能障碍Obesity and Male Sexual Dysfunction[J]. 临床医学进展, 2018, 08(08): 708-714. https://doi.org/10.12677/ACM.2018.88119
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