胃癌中微卫星不稳定亚型是胃癌分型的一大类,其形成机制和分子学构成都有着独特的特征,日益增多的研究表明微卫星不稳定型胃癌及其亚型不管是在基因方面,表观遗传学方面,临床病理特征以及其与不同辅助治疗之间的预后都存在密切的关系。本文就微卫星不稳定的概念,形成及检测方法,与胃癌有关的发病机制,临床和病理特征及与预后有关的研究做一简单综述。 Microsatellite instability is a kind of classification subtype in gastric cancer and its formation mechanism and molecular structure have unique characteristics. A growing number of studies have shown that microsatellite instability and its subtypes have relationship with genetic, epigenetic, clinical pathologic features and the prognosis in different adjuvant therapy. In this paper, we will review the concept, formation and detection methods of microsatellite instability, and the relationship about pathogenesis, clinical and pathological characteristics of gastric cancer.
微卫星不稳定,胃癌,检测方法,临床病理特征,预后, MSI Gastric Cancer Detective Method Clinicopathological Features Prognosis微卫星不稳定(MSI)与胃癌临床及预后的 研究进展
史颖晨,符 号,赵 红. 微卫星不稳定(MSI)与胃癌临床及预后的研究进展Advances in the Study of Microsatellite Instability and Clinical and Prognosis of Gastric Cancer[J]. 亚洲肿瘤科病例研究, 2019, 08(01): 1-6. https://doi.org/10.12677/ACRPO.2019.81001
参考文献ReferencesBray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A. and Jemal, A. (2018) Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68, 394-424. <br>https://doi.org/10.3322/caac.21492Yamamoto, H. and Imai, K. (2015) Mi-crosatellite Instability: An Update. Archives of Toxicology, 89, 899-921. <br>https://doi.org/10.1007/s00204-015-1474-0Yuza, K., Nagahashi, M., Watanabe, S., et al. (2017) Hypermutation and Microsatellite Instability in Gastrointestinal Cancers. Oncotarget, 8, 112103-112115. <br>https://doi.org/10.18632/oncotarget.22783Macpherson, P., et al. (2005) 8-Oxoguanine Incorporation into DNA Repeats in Vitro and Mismatch Recognition by MutSα. Nucleic Acids Research, 33, 5094-5105.Velho, S., Fernandes, M.S., Leite, M., et al. (2014) Causes and Consequences of Microsatellite Instability in Gastric Carcinogenesis. World Journal of Gastroenterology, 20, 16433-16442. <br>https://doi.org/10.3748/wjg.v20.i44.16433Cor-tes-Ciriano, I., Lee, S., Park, W.-Y., Kim, T.-M. and Park, P.J. (2017) A Molecular Portrait of Microsatellite Instability across Multiple Cancers. Nature Communications, 8, 15180. <br>https://doi.org/10.1038/ncomms15180Richman, S. (2015) Deficient Mismatch Repair: Read All about It (Review). International Journal of Oncology, 47, 1189-1202.Murphy, K.M., Zhang, S., Geiger, T., Hafez, M.J., Bacher, J., Berg, K.D., et al. (2006) Comparison of the Microsatellite Instability Analysis System and the Bethesda Panel for the Determination of Microsatellite Instability in Colorectal Cancers. The Journal of Molecular Diagnostics, 8, 305-311. <br>https://doi.org/10.2353/jmoldx.2006.050092Hang, X., Li, D., Wang, J., et al. (2018) Prognostic Significance of Microsatellite Instability-Associated Pathways and Genes in Gastric Cancer. International Journal of Molecular Medicine, 42, 149-160.Sargent, D.J., Marsoni, S., Monges, G., et al. (2010) Defective Mismatch Repair as a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer. Journal of Clinical Oncology, 28, 3219-3226. <br>https://doi.org/10.1200/JCO.2009.27.1825Amira, A.T., Mouna, T., Ahlem, B., et al. (2014) Immunohistochemical Expression Pattern of MMR Protein Can Specifically Identify Patients with Colorectal Cancer Microsatellite Instability. Tumor Biology, 35, 6283-6291. <br>https://doi.org/10.1007/s13277-014-1831-2Boland, C.R., Thibodeau, S.N., Hamilton, S.R., et al. (1998) A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: Development of International Criteria for the Determination of Microsatellite Instability in Colorectal Cancer. Cancer Research, 58, 5248-5257.Mereiter, S., Polom, K., Williams, C., et al. (2018) The Thomsen-Friedenreich Antigen: A Highly Sensitive and Specific Predictor of Microsatellite Instability in Gastric Cancer. Journal of Clinical Medicine, 7, 256. <br>https://doi.org/10.3390/jcm7090256Ottini, L., Falchetti, M., Lupi, R., et al. (2006) Patterns of Genomic Instability in Gastric Cancer: Clinical Implications and Perspectives. Annals of Oncology, 17, vii97-vii102. <br>https://doi.org/10.1093/annonc/mdl960Leung, S.Y., Yuen, S.T., Chung, L.P., et al. (1999) hMLHl Promoter Methylation and Lack of hMLHl Expression in Sporadic Gastric Carcinomas with High-Frequency Microsatellite Instability. Cancer Research, 59, 159-164.Polom, K., Marrelli, D., Roviello, G., et al. (2017) Molecular Key to Understand the Gastric Cancer Biology in Elderly Patients—The Role of Microsatellite Instability. Journal of Surgical Oncology, 115, 344-350. <br>https://doi.org/10.1002/jso.24513Cristescu, R., Lee, J., Nebozhyn, M., et al. (2014) Cancer Genome Atlas Research Network. Comprehensive Molecular Characterization of Gastric Adenocarcinoma. Nature, 513, 202-209. <br>https://doi.org/10.1038/nature13480Mathiak, M., Warneke, V.S., Behrens, H.M., et al. (2017) Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for Standardization. Applied Immunohistochemistry & Molecular Morphology, 25, 12-24. <br>https://doi.org/10.1097/PAI.0000000000000264Marrelli, D., Polom, K., Pascale, V., et al. (2016) Strong Prognostic Value of Microsatellite Instability in Intestinal Type Non-Cardia Gastric Cancer. Annals of Surgical Oncology, 23, 943-950. <br>https://doi.org/10.1245/s10434-015-4931-3Cristescu, R., Lee, J., Nebozhyn, M., et al. (2015) Molecular Analysis of Gastric Cancer Identifies Subtypes Associated with Distinct Clinical Outcomes. Nature Medicine, 21, 449-456. <br>https://doi.org/10.1038/nm.3850Pinto, M., Oliveira, C., Machado, J.C., et al. (2018) Meta-Analysis of Microsatellite Instability in Relation to Clinicopathological Characteristics and Overall Survival in Gastric Cancer. British Journal of Surgery, 105, 159-167. <br>https://doi.org/10.1002/bjs.10663Roth, A.D., Delorenzi, M., Tejpar, S., Yan, P., Klingbiel, D., Fiocca, R., d’Ario, G., Cisar, L., Labianca, R., Cunningham, D., Nordlinger, B., Bosman, F. and Van Cutsem, E. (2012) Integrated Analysis of Molecular and Clinical Prognostic Factors in Stage II/III Colon Cancer. Journal of the National Cancer Institute, 104, 1635-1646.
<br>https://doi.org/10.1093/jnci/djs427Merok, M.A., Ahlquist, T., Røyrvik, E.C., Tufteland, K.F., Hektoen, M., Sjo, O.H., Mala, T., Svindland, A., Lothe, R.A. and Nesbakken, A. (2013) Microsatellite Instability Has a Positive Prognostic Impact on Stage II Colorectal Cancer after Complete Resection: Results from a Large, Consecutive Norwegian Series. Annals of Oncology, 24, 1274-1282. <br>https://doi.org/10.1093/annonc/mds614Bertagnolli, M.M., Redston, M., Compton, C.C., Niedzwiecki, D., Mayer, R.J., Goldberg, R.M., Colacchio, T.A., Saltz, L.B. and Warren, R.S. (2011) Microsatellite Instability and Loss of Heterozygosity at Chromosomal Location 18q: Prospective Evaluation of Biomarkers for Stages II and III Colon Cancer—A Study of CALGB 9581 and 89803. Journal of Clinical Oncology, 29, 3153-3162. <br>https://doi.org/10.1200/JCO.2010.33.0092Sinicrope, F.A., Foster, N.R., Thibodeau, S.N., Marsoni, S., Monges, G., Labianca, R., Kim, G.P., Yothers, G., Allegra, C., Moore, M.J., Gallinger, S. and Sargent, D.J. (2011) DNA Mismatch Repair Status and Colon Cancer Recurrence and Survival in Clinical Trials of 5-Fluorouracil-Based Adjuvant Therapy. Journal of the National Cancer Institute, 103, 863-875. <br>https://doi.org/10.1093/jnci/djr153Sinicrope, F.A., Mahoney, M.R., Smyrk, T.C., Thibodeau, S.N., Warren, R.S., Bertagnolli, M.M., Nelson, G.D., Goldberg, R.M., Sargent, D.J. and Alberts, S.R. (2013) Prognostic Impact of Deficient DNA Mismatch Repair in Patients with Stage III Colon Cancer from a Randomized Trial of FOLFOX-Based Adjuvant Chemotherapy. Journal of Clinical Oncology, 31, 3664-3672. <br>https://doi.org/10.1200/JCO.2013.48.9591Popat, S., Hubner, R. and Houlston, R.S. (2005) Systematic Re-view of Microsatellite Instability and Colorectal Cancer Prognosis. Journal of Clinical Oncology, 23, 609-618. <br>https://doi.org/10.1200/JCO.2005.01.086Gafà, R., Maestri, I., Matteuzzi, M., Santini, A., Ferretti, S., Cavazzini, L. and Lanza, G. (2000) Sporadic Colorectal Adenocarcinomas with High Frequency Microsatellite Instability. Cancer, 89, 2025-2037. <br>https://doi.org/10.1002/1097-0142(20001115)89:10<2025::AID-CNCR1>3.0.CO;2-SGryfe, R., Kim, H., Hsieh, E.T., Aronson, M.D., Holowaty, E.J., Bull, S.B., Redston, M. and Gallinger, S. (2000) Tumor Microsatellite In-stability and Clinical Outcome in Young Patients with Colorectal Cancer. The New England Journal of Medicine, 342, 69-77. <br>https://doi.org/10.1056/NEJM200001133420201Tan, W.J., Hamzah, J.L., Acharyya, S., et al. (2017) Evaluation of Long-Term Outcomes of Microsatellite Instability Status in an Asian Cohort of Sporadic Colorectal Cancers. Journal of Gastrointestinal Cancer, 9454, 1-8.Oki, E., Kakeji, Y., Zhao, Y., et al. (2009) Chemosensitivity and Survival in Gastric Cancer Patients with Microsatellite Instability. Annals of Surgical Oncology, 16, 2510-2515. <br>https://doi.org/10.1245/s10434-009-0580-8Kim, S.Y., Choi, Y.Y., An, J.Y., et al. (2015) The Benefit of Microsatellite Instability Is Attenuated by Chemotherapy in Stage II and Stage III Gastric Cancer: Results from a Large Cohort with Subgroup Analyses. International Journal of Cancer, 137, 819-825. <br>https://doi.org/10.1002/ijc.29449Polom, K., et al. (2018) Synchronous Metastatic Gastric Cancer-Molecular Background and Clinical Implications with Special Attention to Mismatch Repair Deficiency. European Journal of Surgical Oncology, 44, 626-631.