目的:探讨多原发恶性肿瘤的发病情况、临床特点及与生存率之间的相关性。方法:收集我院2014年7月~2019年5月收治865例患者,其中55例为双原发或三原发恶性肿瘤,分析其病历资料。结果:多原发恶性肿瘤患者发病率为6.36%,其中双原发恶性肿瘤为49例,三原发恶性肿瘤为6例,发病率为0.69%。男性27例,女性28例,第一原发恶性肿瘤平均年龄54.84岁,第二原发恶性肿瘤平均年龄为62.7岁,第三原发恶性肿瘤平均年龄为64.33岁。结论:多原发恶性肿瘤以消化道多见,其次为肺癌。高发年龄为40~69岁之间。第一原发恶性肿瘤发病年龄与生存率成正相关,相关系数为0.51。而第二原发恶性肿瘤发病年龄与生存率成明显负相关,相关系数为−0.93。 Objective: To investigate correlation of the incidence, clinical characteristics and survival rate of multiple primary malignant tumors. Methods: 865 cases of malignant tumors were treated in our hospital from July 2014 to May 2019, 55 of them were double or triple primary malignant tumors, and their medical records were analyzed. Results: The incidence of multiple primary malignant tumors was 6.36%, including 49 cases of double primary malignant tumors and 6 cases of three primary malignant tumors. The incidence was 0.69%. There were 27 males and 28 females. The average age of the first primary malignant tumor was 54.84 years; the average age of the second primary malignant tumor was 62.7 years; and the average age of the third primary malignant tumor was 64.33 years. Conclusion: Digestive tract is the most common primary malignant tumor, followed by lung cancer. The high incidence age is between 40 and 69 years old. The age at onset of the first primary malignant tumor was positively correlated with survival rate. The correlation coefficient is 0.51. The age at onset of the second primary malignant tumor was negatively correlated with survival rate. The correlation coefficient is −0.93.
多原发恶性肿瘤,发病年龄,生存率, Multiple Primary Malignant Tumors Age of Onset Survival Rate55例多原发恶性肿瘤回顾性临床分析
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1. 引言
多原发恶性肿瘤(multiple primary malignant tumors, MPMT)越来越受到重视。近来由于肿瘤研究和治疗技术的提高,在初次确诊肿瘤后,随着肿瘤患者存活时间延长,出现第二原发恶性肿瘤可能性增大。尽管对多原发恶性肿瘤存在不同的定义。主要依据SEER (Surveillance, Epidemiology, and End Results)和IACR/IARC (International Association of Cancer Registries and International Agency for Research on Cancer)的定义。多原发恶性肿瘤发病率在2%~17%之间。潜在的因素包括区域、生活相关、环境、遗传因素和治疗相关因素 [1] 。本文对我院2014年7月~2019年5月入住恶性肿瘤患者进行统计分析。探讨发病年龄、性别、间隔时间及发病特征。以提高对多原发恶性肿瘤的认识。
张云波,张建光,刘俊启,郑丽萍. 55例多原发恶性肿瘤回顾性临床分析Retrospective Clinical Analysis of 55 Cases of Multiple Primary Malignant Tumors[J]. 临床医学进展, 2019, 09(11): 1238-1242. https://doi.org/10.12677/ACM.2019.911191
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