肝缺血再灌注损伤(hepatic ischemia reperfusion injury, HIRI)时,体内NO、eNOS减少,iNOS增多。NO减少时,肝窦收缩微循环障碍;肝脏细胞水肿、坏死、凋亡;亚硝酸盐还原为NO增多。NO涉及HIRI的多个环节。损伤早期,eNOS激活产生NO有保护作用,但eNOS过度表达且其衍生NO生物利用度过高可加重肝损伤;而iNOS晚期因大量产生NO产生保护作用。缺血预处理、缺血后处理以及药物预处理则可通过增强eNOS、降低iNOS活性而增加血清NO并降低丙二醛含量,发挥肝脏围术期保护功能。本文综述了近年来NO与HIRI相关性新研究进展。 The levels of eNOS and NO reduced but iNOS increased during hepatic ischemia reperfusion injury (HIRI) in vivo. Once NO reduced, the hepatic sinus was contracted and the microcirculation was damaged; in addition, liver cell edema, necrosis and apoptosis were happened; the levels of serum liver enzymes were also changed; nitrite transforming to NO increased and osteopontin upregulated. NO involves the multiple steps of HIRI. During the early injury, activation of eNOS may play a protective role by its producing NO. However, eNOS over-expression or the excessive bioavailability of derivative NO will aggravate liver injury. At the end of the injury, iNOS can produce higher NO levels to protect liver from HIRI. Ischemic preconditioning, ischemic postconditioning and medicine preconditioning can increase serum NO level by increasing eNOS level and decreasing iNOS activity and reduce the MDA level, which play a protective role in the perioperative period of liver. This article summarizes the newest progress in the relations between NO and HIRI.
肝脏,缺血再灌注损伤,一氧化氮,一氧化氮合酶, Liver Ischemia Reperfusion Injury NO NOS一氧化氮与肝缺血再灌注损伤相关性研究新进展
张亚奇,丁 宁,向圆圆,曾永芬,洪芬芳,杨树龙. 一氧化氮与肝缺血再灌注损伤相关性研究新进展New Progress in the Relations between Nitric Oxide and Hepatic Ischemia Reperfusion Injury[J]. 药物资讯, 2017, 06(05): 101-107. http://dx.doi.org/10.12677/PI.2017.65017
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