猪流行性腹泻病毒(PEDV)是一种肠道致病菌。它引起仔猪流行性腹泻,这是许多国家在畜牧业中出现重大经济损失的最重要原因之一。在某种程度上,Toll样受体(TLRs)的转录和干扰素(IFN)的激活这两种先天免疫反应对抗病毒免疫有一定的影响。后者在抵御病毒感染的防御中发挥了关键作用。PEDV可以有效通过屏障感染宿主。宿主细胞有一系列复杂的策略来抵抗病毒。目前已经发现,在一些研究中,PEDV调控的宿主先天固有免疫出现了很大的提升。为了逃避宿主–先天免疫反应,PEDV采取了两种方法,PEDV将病毒蛋白编码为干扰素拮抗剂,其病原体相关的分子模式(PAMPs)被隐藏。PEDV的非结构蛋白和一些蛋白酶对这一过程有一定的影响。本文介绍了当前对宿主细胞抗PEDV的先天免疫反应,这过程涉及了PEDV的结构性和非结构性的主要蛋白质,并且分析了几个PEDV入侵细胞的关键机制,进一步为探索PEDV传染性免疫和致病机制提供重要的理论依据,并为临床疫苗或药物研究提供主要的实践支撑。 Porcine epidemic diarrhea virus (PEDV) is a central intestinal pathogen, causing porcine epidemic diarrhea in piglets, which is one of the most vital reasons why plenty of countries have been caught sight of substantial economic losses in animal husbandry. About innate immune response, to some extent, Toll-like receptors (TLRs), transcription and activation of interferon (IFN) resulted in a few influences on anti-virus immune. The latter was served as a critical role in the defensive shields against the viral infection. The host could be efficaciously infected by PEDV through the obstacle. There are series of sophisticated strategies to resist virus for host cells. Currently it has been spotted that excellent improvement took place in some studies about the host innate in munity regulated by PEDV. To escape from host-innate immune response PEDV adopts two approaches, originally PEDV encodes viral proteins as interferon antagonists, and its pathogen-associated molecular patterns (PAMPs) would be hided then remain undercover. Non-structural proteins and some proteases of PEDV have been posed some impact on the process. This review illustrates the current grasp on innate immune response of host cells to anti-PEDV covering major proteins between the structural and the non-structural of PEDV to analyze several critical mechanisms on cellular entry of porcine epidemic diarrhea virus, further providing important theoretical grounds for exploring infectious immunity and pathogenic mechanisms of PEDV and supplying the main practical support for its clinical vaccines or medicine research.
猪流行性腹泻病毒,先天免疫反应,N蛋白,非结构蛋白, Porcine Epidemic Diarrhea Virus Innate Immune Response N Protein Non-Structural Proteins猪流行性腹泻病毒的结构和非结构蛋白 应对宿主细胞先天性免疫
袁 芃,杨 舟,王 凯,杨 洋,黄石磊,谢录异,宋振辉. 猪流行性腹泻病毒的结构和非结构蛋白应对宿主细胞先天性免疫 Structural and Non-Structural Proteins of Porcine Epidemic Diarrhea Virus against Congenital Immunity of Host Cells[J]. 微生物前沿, 2018, 07(02): 39-47. https://doi.org/10.12677/AMB.2018.72005
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