微小RNA(microRNA, miRNA)是一类长度约22个核苷酸的内源性非编码RNA,可通过与靶基因mRNA的3’端非编码区(3’UTR)结合实现基因在转录水平后的调控。自噬(Autophagy)是存在于真核细胞中高度保守的、降解受损细胞器和其他大分子物质的一种途径。自噬功能的异常会导致变性蛋白和损伤细胞器的积累,参与帕金森病等神经退行性疾病的发生。有研究表明微小RNA能够通过调节自噬在帕金森病中发挥重要作用。
microRNAs (miRNAs) are endogenous approximately 22 nucleotide non-coding RNAs that post-transcriptionally regulate gene expression via binding to 3’ untranslated regions. Autophagy is a highly conserved pathway for the degradation of damaged organelles and other macromolecular substances in eukaryotic cells. Abnormal autophagy leads to the accumulation of denatured proteins and damaged organelles, and is involved in the development of neurodegenerative dis-eases such as Parkinson’s disease. Studies have shown that microRNAs play an important role in Parkinson’s disease by regulating autophagy.
李 伟,李 舒. 微小RNA对自噬的调控机制及其在帕金森病中的作用 microRNA Regulates Autophagy and Its Role in Parkinson’s Disease[J]. 临床医学进展, 2018, 08(02): 160-164. https://doi.org/10.12677/ACM.2018.82027
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