瘙痒是机体生理状态下自我保护的一种反应机制,也是很多系统性疾病和皮肤疾病的症状之一。本文就瘙痒的分类,引起瘙痒的分子机制,与组胺受体的联系,瘙痒的评价和测量方法以及瘙痒的治疗做一个综述。
Itching is a mechanism of self-protection in the body’s physiological state and is one of the symp-toms of many systemic diseases and skin diseases. This paper presents a review of the classification of itching, the molecular mechanisms of causing itching. This paper describes the association between itching and histamine receptors, and provides a method for the evaluation and meas-urement of itching and how to treat itching.
瘙痒,分类,机制,联系,评价与测量方法,治疗, Itching Classification Mechanism Contact Evaluation and Measurement Method Treatment瘙痒的研究进展
陈路遥,胡文祥,姚 磊. 瘙痒的研究进展 The Basic Research Progress in Pruritus[J]. 比较化学, 2018, 02(03): 100-108. https://doi.org/10.12677/CC.2018.23012
参考文献References丁媛, 普雄明. 瘙痒的发生机制、相关疾病和治疗[J]. 中国麻风皮肤病杂志, 2006, 22(6): 492-495.Bergasa, N.V. (2004) An Approach to the Management of the Pruritus of Cholestasis. Clinics in Liver Disease, 8, 55-56. https://doi.org/10.1016/S1089-3261(03)00128-4Singh, F. and Rudikoff, D. (2003) HIV-Associated Pruritus. Springer Link, 4, 177-188.
https://doi.org/10.2165/00128071-200304030-00004樊建勇, 刘玉峰. 瘙痒发生的神经生理学研究进展[J]. 国际病理科学与临床杂志, 2006, 26(6): 511-514.Andrew, D. and Craig, A.D. (2001) Spinothalamic Jamina Neurons Selectively Sensitive to Histamine: A Central Neural Pathy Way for Itch. Nature Neuroscience, 4, 72-77. https://doi.org/10.1038/82924Darsow, U., Drzezga, A., Frisch, M., et al. (2000) Processing of Histamine Induced Itch in the Human Cerebral Cortex: A Correlation Analysis with Dermal Reactions. Journal of Investigative Dermatology, 115, 1029-1033.
https://doi.org/10.1046/j.1523-1747.2000.00193.xIkoma, A., Rukwied, R., Stander, S., et al. (2003) Neu-rophysiology of Pruritus: Interaction of Itch and Pain. Archives of Dermatology, 139, 1475-1478. https://doi.org/10.1001/archderm.139.11.1475Stander, S., Steinhoff, M., Schmelz, M., et al. (2003) Neu-rophysiology of Pruritus: Cutaneous Elicitation of Itch. Archives of Dermatology, 139, 1463-1470. https://doi.org/10.1001/archderm.139.11.1463黄建国. 5-羟色胺与瘙痒[J]. 中国皮肤性病学杂志, 2014, 28(10): 1072-1074 + 1082.黄林雪, 李利. 皮肤源性慢性瘙痒神经生理机制研究进展[J]. 中国中西医结合皮肤性病学杂志, 2015, 14(4): 265-269.Ohkubo, T., Shibata, M., Inoue, M., et al. (1995) Regulation of Substance P Release Mediated via Prejunctional Histamine H3 Receptors. European Journal of Pharmacology, 273, 83-88. https://doi.org/10.1016/0014-2999(94)00668-WTwycross, R., Greaves, M.W., Handwerker, H., et al. (2003) Itch: Scratching More than the Surface. QJM, 96, 7-26.
https://doi.org/10.1093/qjmed/hcg002柴国东, 杨泽群. TRP通道与痒的研究进展[J]. 内蒙古医学杂志, 2017(10): 1181-1184.Shim, W.S., Tak, M.H., Lee, M.H., et al. (2007) TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2 and 12-Lipoxygenase. Journal of Neuroscience, 27, 2331-2337.
https://doi.org/10.1523/JNEUROSCI.4643-06.2007Yamaguchi, T. (1999) Itch-Associated Response In-duced by Intradermal Serotonin through 5-HT2 Receptors in Mice. Neuroscience Research, 35, 77-83. https://doi.org/10.1016/S0168-0102(99)00070-X野岛浩史. 动物におけるかゅみの评价[J]. 医学あゅみ, 2001, 197: 587-589.Wallengren, J. and Sundler, F. (2004) Phototherapy Reduces the Number of Epidermal and CGRP-Positive Dermal Nerve Fibres. Acta Dermato-Venereologica, 84, 111-115. https://doi.org/10.1080/00015550310022899Nilsson, H.J., Psouni, E., Carstam, R., et al. (2004) Profound Inhibition of Chronicitch Induced by Stimulation of Thin Cutaneous Nerve Fibres. Journal of the European Academy of Dermatology and Venereology, 17, 37-43.Lysy, J., Sistiery-Ittah, M., Israelit, Y., et al. (2003) Topical Capsaicina Novel and Effective Treatment for Idiopathic Intractable Pruritus ani: Arandomised, Placebo Controlled, Crossover Study. Gut, 52, 1323-1326.
https://doi.org/10.1136/gut.52.9.1323Stander, S., Luger, T. and Metze, D. (2001) Treatment of Pru-rigonodularis with Topical Capsaicin. Journal of The American Academy of Dermatology, 44, 471-478. https://doi.org/10.1067/mjd.2001.110059Stander, S. and Luger, T.A. (2003) Antipruritic Effects of Pimecrolimus and Tacrolimus. Hautarzt, 54, 413-417.Brune, A., Metze, D. and Luger, T.A. (2004) Antipruritische therapie mit dem oralen opiatrezeptorantagonisten Naltrexon. Der Hautarzt, 55, 1130-1136.Zylicz, Z., Krajnik, M. and Sorge, A.A. (2003) Paroxetine in the Treatment of Severe Non-Dermatological Pruritus: A Randomized, Controlled Trial. Journal of Pain and Symptom Management, 26, 1105-1112.
https://doi.org/10.1016/j.jpainsymman.2003.05.004Daly, B.M. and Shuster, S. (2000) Antipruritic Action of Thalidomide. Acta Dermato-Venereologica, 80, 24-25.
https://doi.org/10.1080/000155500750012450Schumann, R. and Hudcova, J. (2004) Cholestasis of Preg-nancy, Pruritus and 5-Hydroxytryptamine 3 Receptor Antagonists. Acta Obstetricia et Gynecologica Scandinavica, 83, 861-862.Davis, M.P., Frandsen, J.L., Walsh, D., et al. (2003) Mirtazapine for Pruritus. Journal of Pain and Symptom Management, 25, 288-291. https://doi.org/10.1016/S0885-3924(02)00645-0Undley, J.L. and Yo-sipovitch, G. (2004) Mirtazapine for Reducing Nocturnal Itch in Patients with Chronic Pruritus: Apilol Study. Journal of the American Academy of Dermatology, 50, 889-891.
https://doi.org/10.1016/j.jaad.2004.01.045谢志强. 慢性瘙痒发生机制研究进展[J]. 中国医学文摘皮肤科学, 2015(32): 579-585.Paus, R., Schmelz, M., Biro, T., et al. (2006) Frontiers in Pruritus Research: Scratching the Brain for More Effective Itch Therapy. The Journal of Clinical Investigation, 116, 1174-1186. https://doi.org/10.1172/JCI28553Venuprasad, K., Elly, C., Gao, M., et al. (2006) Convergence of Itch-Induced Ubiquitination with MEKK1-JNK Signaling in Th2 Tolerance and Airway Inflammation. The Journal of Clinical Investigation, 116, 1117-1126.
https://doi.org/10.1172/JCI26858