核苷酸结合寡聚化结构域样受体3 (NLRP3),是胞质型模式识别受体NOD样受体(pyrin domain con-taining, NLR)家族的一员,属于NLR家族中的一个典型代表。NLRP3炎性小体能活化胱天蛋白酶(caspase-1),进一步剪切IL-1β、IL-18前体,使其成为有活性的促炎因子再释放,来参与机体抵抗病原体的免疫应答。近来研究发现,系性红斑狼疮(SLE)患者血清IL-1β、IL-18水平升高,且与SLE严重程度密切相关。本文综述了NLRP3的结构、激活方式及与SLE疾病的研究进展,为寻求更精准的靶向治疗途径作参考。
NLRP3 is one of the members of NOD and belongs to a typical representative in NLR family. In-flammasome of NLRP3 is able to activate caspase-1 and further shears IL-1β, IL-18 precusor, to make them active proinflammatory factor which will be released in order to participate in the immune response in organism’s resistance to pathogene. Recent researches showed that SLE pa-tients’ serum levels of IL-1β and IL-18 about SLE patients were elevated and these levels are closely related to the severity of SLE. This article summarizes the structure and activation method of NLRP3 as well as its research progress with SLE so as to search for more accurate targeted therapy approach which can be a reference.
王嘉妮,曹慧琴,刘宇宏. NLRP3炎性小体与系统性红斑狼疮的相关研究 Related Research on NLRP3 Inflammasome and SLE[J]. 临床医学进展, 2018, 08(06): 544-548. https://doi.org/10.12677/ACM.2018.86090
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