结肠息肉是常见的结肠疾病之一,其中腺瘤性息肉被认为是结肠癌的癌前状态,幽门螺杆菌(Helicobacter pylori, Hp)感染与结肠息肉的关系逐渐被研究学者所关注,有研究者报道Hp感染可能会增加结肠息肉和结肠癌的发病率,但也有学者不支持这一观点,认为Hp感染与结肠息肉、结肠癌的发生没有相关性。Hp感染可能导致结肠息肉甚至结肠癌的机制主要是与胃泌素及环氧合酶-2 (cyclooxygenase-2, COX-2)有关。我们是否可通过抑制胃泌素水平及根除HP来减少结肠息肉及结肠癌的发生率,为结肠息肉、结肠癌的防治提供依据,仍有待于深入研究。
Colonic polyp is one of the common colon diseases, including adenomatous polyp. It is considered to be before-cancer state of colon cancer. The relationship between Helicobacter pylori (Hp) infection and colon polyps has been concerned by researchers, and some researchers have reported that Hp infection may increase the incidence of colon polyps and colon cancer, but there are also scholars who do not support this view, that Hp infection is not associated with the incidence of colon polyps and colon cancer. The mechanism of Hp infection may lead to colon polyps and even colon cancer is mainly related to gastrin and cyclooxygenase-2. Whether we can reduce the incidence of colonic polyps and colon cancer by inhibiting gastrin level and eradicating Hp, and provide a basis for the prevention and treatment of colonic polyps and colon cancer remains to be further studied.
孙红梅,武金宝. 幽门螺旋杆菌在结肠息肉发病中的研究进展 Progress of Helicobacter pylori in the Pathogenesis of Colonic Polyps[J]. 世界肿瘤研究, 2018, 08(04): 127-131. https://doi.org/10.12677/WJCR.2018.84020
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