膳食纤维(dietary fiber, DF)或抗性淀粉(resistant starch, RS)等益生元在肠道中被肠道细菌发酵,主要产物为短链脂肪酸(short-chain fatty acid, SCFAs)。短链脂肪酸可以通过多种途径对糖尿病产生有益的影响。肠道微生物群也与糖尿病发病机制密切相关,其在宿主免疫系统、饮食中的能量摄入以及人类基因表达的改变方面都起着至关重要的作用。本综述旨在总结肠道微生物群和短链脂肪酸在糖尿病中的作用来促进使用益生元和益生菌来预防和治疗这些代谢紊乱疾病综合策略的发展。 Prebiotics, such as dietary fiber (DF) and resistant starch, are fermented into SCFAs in the colon by certain communal bacterial species. The main product of fermentation is short-chain fatty acids. SCFAs can have a beneficial impact on diabetes in many ways. Gut microbiota is strongly associated with diabetes development. Gut bacteria play a crucial role in the host immune system, extraction of energy from the host diet and alterations of human gene expression. The review aims at the role of total colon microbiota and short-chain fatty acids in diabetes to promote the use of prebiotics and probiotics to prevent and treat the development of comprehensive strategies for these metabolic disorders.
庞 博,任军丽,杨修利,单毓娟. 短链脂肪酸对糖尿病的调节机制及应用The Mechanism and Application of Short-Chain Fatty Acids in Diabetes Mellitus[J]. 食品与营养科学, 2018, 07(04): 350-356. https://doi.org/10.12677/HJFNS.2018.74043
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