肿瘤微环境具有低pH值、高温、高浓度的还原型谷胱甘肽(GSH)等特点。利用这些特点作为刺激因子,设计敏感性的纳米给药系统有可能显著提高抗肿瘤药物的治疗效果。本文主要论述了温敏性、pH敏感性、氧化还原敏感性和多重敏感性纳米给药系统的研究进展,希望为纳米给药系统的设计和肿瘤治疗提供新思路。
The tumor microenvironment has characteristics with low pH value, high temperature, high con-centration of glutathione (GSH) and so on. By using these characteristics as a stimulating factor, design of sensitive nano drug delivery system could significantly improve the therapeutic effect of anti tumor drugs. This paper mainly discusses the research progress of temperature sensitivity, pH sensitivity, redox sensitivity and multiple-sensitivity nano drug delivery systems, to provide new ideas for design of nano delivery system and cancer treatment.
纳米给药系统,敏感性,肿瘤微环境, Nano Drug Delivery Systems Sensitivity Tumor Microenvironment肿瘤微环境敏感性纳米给药系统的研究
Chi等 [30] 为改善骨肉瘤的化疗效果,开发了一种氧化还原敏感性的CD44靶向的脂质体。通过引入二硫键将胆固醇(Chol)和PEG偶联,合成了具有氧化还原敏感性的Chol-SS-mPEG阳离子型脂质体,并通过非共价作用将CD44靶向的透明质酸包裹在其表面,形成具有氧化还原敏感性的Chol-SS-mPEG/HA-L靶向脂质体。以DOX作为模型药物,体外药物释放实验发现在含有10 mM GSH的情况下可以观察到60%的爆发释放;MTT细胞活性测定显示,载药的Chol-SS-mPEG/HA-L对MG63骨肉瘤细胞的细胞毒性明显高于非还原敏感性的载药脂质体;动物实验表明,载药敏感性脂质体显示出最有效的肿瘤抑制作用,且肝脏摄取量最小。Chol-SS-mPEG/HA-L是一种良好的细胞内传递系统,具有GSH触发的细胞质药物释放功能,是一种较为理想的抗肿瘤药物载体。
曾晨星,李 蓉,张 佩,贺 艳,尹玉利,王 欢,刘 阳. 肿瘤微环境敏感性纳米给药系统的研究 Research Progress of Tumor Microenvironment-Sensitive Nano Drug Delivery Systems[J]. 材料科学, 2019, 09(03): 218-224. https://doi.org/10.12677/MS.2019.93029
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