幽门螺杆菌(HP)是一种能够长期定植于胃黏膜的革兰阴性杆菌。HP感染可导致慢性胃炎、消化性溃疡、胃癌和胃黏膜相关淋巴组织淋巴瘤,近几年的研究显示HP感染与肠道外的疾病也有一定的相关性。代谢综合征(MS)是以腹型肥胖、脂代谢异常、高血压、糖尿病、高尿酸血症等合并症为特点的一组临床症候群,以多种物质代谢异常为基础的病理生理改变,存在多个致动脉粥样硬化危险因素,最终导致心脑血管疾病的发生和发展。近些年来,越来越多的研究显示出HP感染与MS之间有一定的相关性。
Helicobacter pylori (HP) is a Gram-negative bacillus that can colonize the gastric mucosa for a long time. HP infection can lead to chronic gastritis, peptic ulcer, gastric cancer and gastric muco-sa-associated lymphoid tissue lymphoma. In recent years, studies have shown that HP infection is also associated with extraintestinal diseases. Metabolic syndrome (MS) is a group of clinical syn-dromes characterized by abdominal obesity, abnormal lipid metabolism, hypertension, diabetes, hyperuricemia and other comorbidities. Pathophysiological changes based on abnormal metabo-lism of various substances exist. Multiple risk factors for atherosclerosis ultimately lead to the development and progression of cardiovascular and cerebrovascular diseases. In recent years, more and more studies have shown a certain correlation between Hp infection and MS.
王 正,戴光荣. 幽门螺杆菌感染与代谢综合征的相关性研究The Correlation between Helicobacter pylori Infection and Metabolic Syndrome[J]. 临床医学进展, 2019, 09(04): 573-577. https://doi.org/10.12677/ACM.2019.94088
参考文献References陈晶, 刘明, 晁艳茹, 等. 幽门螺杆菌感染对冠心病患者相关炎性因子的影响分析[J]. 中华医院感染学杂志, 2016, 26(15): 3414-3416.张颖, 江勇. 幽门螺杆菌与代谢疾病相关性的研究进展[J]. 中华全科医师杂志, 2016, 15(4): 310-313.杜洁, 杨维, 张桂侠, 等. 幽门螺杆菌感染与血脂代谢及动脉粥样硬化的相关性[J]. 现代检验医学杂志, 2017, 32(4): 104-106.Papamichael, K.X., Papaioannou, G., Karga, H., et al. (2009) Heli-cobacter pylori Infection and Endocrine Disorders: Is There a Link? World Journal of Gastroenterology, 15, 2701-2707. <br>https://doi.org/10.3748/wjg.15.2701Ando, T., Minami, M., Ishiguro, K., et al. (2006) Changes in Biochemical Parameters Related to Atherosclerosis after Helicobacter pylori, Eradication. Alimentary Pharmacology & Therapeutics, 2, 58-64.
<br>https://doi.org/10.1111/j.1746-6342.2006.00026.xKanbay, M., Cur, G. and Yueel, M. (2005) Does Eradica-tion of Helicobacter pylori Infection Help Normalize Serum Lipid and CRP Levels. Digestive Diseases and Sciences, 50, 1228-1231. <br>https://doi.org/10.1007/s10620-005-2764-9徐洋慧, 杨俊. 健康体检人群幽门螺杆菌感染与血脂异常关系的分析[J]. 心脑血管病防治, 2014, 14(2): 163-164.Amrani, A., Baba Hamed, M.B. and Mesli Talebbendiab, F. (2015) Association Study between Some Renin-Angiotensin System Gene Variants and Essential Hy-pertension in a Sample of Algerian Population: Case Control Study. Annales de Biologie Clinique (Paris), 73, 557-563.槐永军, 张桂驰, 柳惠玲. 幽门螺杆菌感染与原发性高血压及高血压心脏病的关系[J]. 临床军医杂志, 2014, 42(11): 1113-1114.张蕾, 王枚, 李霞. 原发性高血压与幽门螺旋杆菌感染的相关性研究[J]. 心脑血管病防治, 2017, 17(2): 146-148.Vahdat, K., Pourbehi, M.R., Ostovar, A., et al. (2013) Association of Pathogen Burden and Hypertension: The Persian Gulf Healthy Heart Study. American Journal of Hypertension, 26, 1140-1147. <br>https://doi.org/10.1093/ajh/hpt083Rasmi, Y., Raeisi, S. and Seyyed Mohammadzad, M.H. (2012) Association of Inflammation and Cytotoxin-Associated Gene a Positive Strains of Helicobacter pylori in Cardiac Syndrome X. Helicobacter, 17, 116-120.
<br>https://doi.org/10.1111/j.1523-5378.2011.00923.x杨光, 王前胜, 吕云霞, 等. 原发性高血压患者幽门螺杆菌感染及C–反应蛋白变化研究[J]. 中华医院感染学杂志, 2016, 26(12): 2735-2737.Migneco, A., Ojetti, V., Specchia, L., et al. (2003) Eradication of Helicobacter pylori Infection Improves Blood Pressure Values in Patients Affected by Hypertension. Helicobacter, 8, 585-589.
<br>https://doi.org/10.1111/j.1523-5378.2003.00180.xZekry, O.A. and Abd Elwahid, H.A. (2013) The Associa-tion between Helicobacter pylori Infection, Type 1 Diabetes Mellitus, and Autoimmune Thyroiditis. Journal of the Egyptian Public Health Association, 88, 143-147.
<br>https://doi.org/10.1097/01.EPX.0000437621.23560.deEl-Eshmawy, M.M., El-Hawary, A.K., Abdel Gawad, S.S. and El-Baiomy, A.A. (2011) Helicobacter pylori Infection Might Be Responsible for the Interconnection between Type 1 Diabetes and Autoimmune Thyroiditis. Diabetology & Metabolic Syndrome, 3, 28. <br>https://doi.org/10.1186/1758-5996-3-28Chobot, A., Bak-Drabik, K., Skała-Zamorowska, E., Krzywicka, A., Kwiecień, J. and Polańska, J. (2014) Helicobacter pylori Infection in Type 1 Diabetes Children and Adolescents Using 13C Urea Breath Test. Polish Journal of Microbiology, 63, 63-67.Sfarti, C., Trifan, A., Hutanasu, C., Cojocariu, C., Singeap, A.M. and Stanciu, C. (2010) Prevalence of Gastroparesis in Type 1 Diabetes Mellitus and Its Relationship to Dyspeptic Symptoms. Journal of Gastrointestinal and Liver Diseases, 19, 279-284.Hamed, S.A., Amine, N.F., Galal, G.M., Helal, S.R., Tag El-Din, L.M., Shawky, O.A., Ahmed, E.A. and Abdel Rahman, M.S. (2008) Vascular Risks and Complications in Diabetes Mellitus: The Role of Helicobacter pylori Infection. Journal of Stroke and Cere-brovascular Diseases, 17, 86-94. <br>https://doi.org/10.1016/j.jstrokecerebrovasdis.2007.10.006岳春艳, 董陆玲. 幽门螺杆菌感染与1型糖尿病的相关性Meta分析[J]. 世界华人消化杂志, 2016, 24(7): 1134-1140.岳春艳, 杨彩哲, 刘朝阳, 杨殷. 幽门螺杆菌感染与胰岛素抵抗水平关系的Meta分析[J]. 世界华人消化杂志, 2015, 23(32): 5238-5249.Polyzos, S.A., Kountouras, J. and Zavos, C. (2009) Nonalcoholic Fatty Liver Disease:The Pathogenetic Roles of Insulin Resistance and Adipocytokines. Current Molecular Medicine, 9, 299-314.
<br>https://doi.org/10.2174/156652409787847191Wang, F., Liu, J. and Lv, Z. (2013) Association of Helico-bacter pylori Infection with Diabetes Mellitus and Diabetic Nephropathy: A Meta-Analysis of 39 Studies Involving more than 20,000 Participants. Scandinavian Journal of Infectious Diseases, 45, 930-938. <br>https://doi.org/10.3109/00365548.2013.844351戴光荣, 冯义朝, 屈彩云, 等. 幽门螺杆菌与胰岛素抵抗之间的关系的研究[C]//中华医学会. 2008 中华消化病学年度讲坛论文集: 2008年卷. 北京: 中国误诊学杂志, 2008: 51-53.王东东. HP感染对高血压患者空腹血糖和胰岛素敏感性及HS–CRP的影响[J]. 河南医学高等专科学校学报, 2018, 30(1): 47-48.Gunji, T., Matsuhashi, N., Sato, H., et al. (2008) Helicobacter pylori Infection Is Significantly Associated with Metabolic Syndrome in the Japanese Population. American Journal of Gastroenterology, 103, 3005-3010.许柯, 许青田, 左路. 幽门螺杆菌感染与2型糖尿病相关性研究[J]. 河南预防医学杂志, 2018, 29(3): 174-176.Gen, R., Demir, M. and Ataseven, H. (2010) Effect of Helicobacter pylori Eradication on Insulin Resistance, Serum Lipids and Low-Grade Inflammation. The Southern Medical Journal, 103, 190-196.
<br>https://doi.org/10.1097/SMJ.0b013e3181cf373f李晓燕, 李晓华, 王养维. 幽门螺杆菌感染与2型糖尿病发病机制的相关性探讨[J]. 现代检验医学杂志, 2017, 32(1): 1-4.Chen, L.-W., Chien, C.-Y., Yang, K.-J., Kuo, S.-F., Chen, C.-H. and Chien, R.-N. (2015) Helicobacter pylori Infection Increases Insulin Resistance and Metabolic Syndrome in Residents Younger than 50 Years Old: A Community-Based Study. PLoS ONE, 10, e128671. <br>https://doi.org/10.1371/journal.pone.0128671林秀雯, 柯小瑚. 代谢综合征及其组分与尿酸的相关性分析[J]. 哈尔滨医药, 2016, 36(2): 138-139.于珍珍, 陈慧, 杨晓云, 等. 高尿酸血症、幽门螺杆菌感染与代谢综合征的相关性[J]. 山东大学学报(医学版), 2017, 55(5): 76-80.