视网膜母细胞瘤(retinoblastoma, RB)是婴幼儿最常见的眼内恶性肿瘤,临床表现复杂,可表现为结膜充血水肿、角膜水肿、虹膜新生血管、玻璃体混浊、眼压升高及斜视等。本病易发生颅内及远处转移,常危及患儿生命,因此早发现、早诊断及早治疗是提高其治愈率、降低死亡率的关键。近年来,该病的治疗方式也不断发展,从最初的手术治疗,到近年研究较热的玻璃体腔内注射化疗药物、眼动脉介入治疗、基因靶点治疗等。随着分子生物学水平技术的发展、基因诊断和治疗水平的提高及分子测序技术的广泛应用,人类对该病本质的认识更加深刻,基因靶向治疗将成为未来治疗的潜在策略。本文阐述了视网膜母细胞瘤的治疗方法并对其未来的治疗方向进行了展望。
Retinoblastoma (RB) is the most common intraocular malignant tumor in infants and young chil-dren. The clinical manifestations are complex, which can be characterized by conjunctival conges-tion and edema, corneal edema, iris neovascularization, vitreous opacity, elevated intraocular pressure and strabismus. The disease is prone to intracranial and distant metastasis, often en-dangering the life of the child, so early detection, early diagnosis and early treatment are the keys to improve the cure rate and reduce mortality. In recent years, the treatment of this disease has also been continuously developed, from the initial surgical treatment to the recent research on hot intravitreal injection of chemotherapy drugs, intra-arterial chemotherapy, gene target therapy. With the development of molecular biology techniques, the improvement of gene diagnosis and treatment level and the wide application of molecular sequencing technology, human beings have a deeper understanding of the nature of the disease, and gene target treatment will become a po-tential strategy for future treatment. This article describes the progress in the treatment of reti-noblastoma, focusing on the progress of gene therapy and future treatment directions.
杨 凡,柴 昌. 视网膜母细胞瘤治疗的研究进展 Progress in the Treatment of Retinoblastoma[J]. 世界肿瘤研究, 2019, 09(03): 75-81. https://doi.org/10.12677/WJCR.2019.93011
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