目的:归纳总结国内外有关茶多酚类化合物的药理活性的研究进展,为其在食品、医疗等领域的研究与应用提供科学依据。方法:通过调查研究近年来国内外相关领域发表的文献,归纳总结茶多酚类化合物在各领域的研究进展。结果:茶多酚类化合物具有很好的抗肿瘤,抗氧化,预防心血管疾病,肝脏保护作用,抑菌作用等等药理活性,且在动物、食品、运动领域均有很好的应用前景。结论:茶多酚作为天然存在的、安全的绿色的化合物,在众多方面呈现出的作用效果足以引起科学界的广泛关注,相信其未来将会有更多更好的应用前景。 This review is to provide scientific evidences for tea polyphenols in foods, medicine and other fields through summarizing the research progress of pharmacological activities of tea polyphenols at domestic and abroad in recent years. Methods: Through investigating many published literatures, the development and applications of tea polyphenols are introduced in this paper. Results: Tea polyphenols have good anti-tumor, anti-oxidation, prevention of cardiovascular disease, liver protection, antibacterial and other pharmacological activities, and have shown enormous potential in multitudinous fields. Conclusion: As the green and safe compounds which are widely found in nature and have many potential medicinal values, tea polyphenols are enough to cause widespread concern in the scientific community. It is believed that there will be more and more applications of tea polyphenols in the future.
石晓玉,邓宝玲,张 燕,张国营. 浅谈茶多酚活性研究进展Advances in Research on Pharmacological Activities of Tea Polyphenols[J]. 药物资讯, 2020, 09(01): 1-6. https://doi.org/10.12677/PI.2020.91001
参考文献References郭颖, 陈琦, 黄峻榕, 吴雪原, 吴琼. 茶叶滋味其品质成分的关系[J]. 茶叶通讯, 2015, 42(3): 13-15+28.Xing, L., Zhang, H., Qi, R., Tsao, R. and Mine, Y. (2019) Recent Advances in the Understanding of the Health Benefits and Molecular Mechanisms Associated with Green Tea Polyphenols. Journal of Agricultural and Food Chemistry, 67, 1029-1043. <br>https://doi.org/10.1021/acs.jafc.8b06146Wang, S., Moustaid-Moussa, N., Chen, L., Mo, H., Shastri, A., Su, R., Shen, C.L., et al. (2014) Novel Insights of Dietary Polyphenols and Obesity. The Journal of Nutritional Biochemistry, 25, 1-18.
<br>https://doi.org/10.1016/j.jnutbio.2013.09.001程浩, 柳序, 曲湘勇. 茶多酚的生物学功能及其在家禽养殖中的应用[J]. 湖南饲料, 2019(3): 32-35.Kishore, S.P., Blank, E., Heller, D.J., Patel, A., Peters, A., Price, M., Vedanthan, R., et al. (2018) Modernizing the World Health Organization List of Essential Medicines for Preventing and Controlling Cardiovascular Diseases. Journal of the American College of Cardiology, 71, 564-574. <br>https://doi.org/10.1016/j.jacc.2017.11.056张丕伟. 茶多酚对高糖作用下内皮细胞自噬流的影响[D]: [硕士学位论文]. 武汉: 华中科技大学, 2016.Ojelabi, O.A., Lloyd, K.P., De Zutter, J.K. and Carruthers, A. (2018) Red Wine and Green Tea Flavonoids Are Cis-Allosteric Activators and Competitive Inhibitors of Glucose Transporter 1 (GLUT1)-Mediated Sugar Uptake. The Journal of Biological Chemistry, 293, 19823-19834. <br>https://doi.org/10.1074/jbc.RA118.002326Cao, Y., Wang, D., Wang, X., Zhang, J., Shan, Z. and Teng, W. (2013) (−)-Epigallocatechin Gallate Inhibits TNF-Alpha- Induced PAI-1 Production in Vascular Endothelial Cells. Jour-nal of Cardiovascular Pharmacology, 62, 452-456. <br>https://doi.org/10.1097/FJC.0b013e3182a18ba8Yamagata, K., Xie, Y., Suzuki, S. and Tagami, M. (2015) Epigallocatechin-3-Gallate Inhibits VCAM-1 Expression and Apoptosis Induction Associated with LC3 Expressions in TNF Alpha-Stimulated Human Endothelial Cells. Phytomedicine, 22, 431-437. <br>https://doi.org/10.1016/j.phymed.2015.01.011Rasheed, N.O., Ahmed, L.A., Abdallah, D.M. and El-Sayeh, B.M. (2017) Nephro-Toxic Effects of Intraperitoneally Injected EGCG in Diabetic Mice: Involvement of Oxidative Stress, Inflammation and Apoptosis. Scientific Reports, 7, Article No. 40617. <br>https://doi.org/10.1038/srep40617Zhang, Q., Yuan, H., Zhang, C., Guan, Y., Wu, Y., Ling, F., Li, Y., et al. (2018) Epigallocatechin Gallate Improves Insulin Resistance in HepG2 Cells through Alleviating Inflammation and Lipotoxicity. Diabetes Research and Clinical Practice, 142, 363-373. <br>https://doi.org/10.1016/j.diabres.2018.06.017He, Q., Bao, L., Zimering, J., Zan, K., Zhang, Z., Shi, H., Cui, G., et al. (2015) The Protective Role of (−)-Epigallocatechin-3-Gallate in Thrombin-Induced Neuronal Cell Apoptosis and JNK-MAPK Activation. Neuroreport, 26, 416-423. <br>https://doi.org/10.1097/WNR.0000000000000363Xie, H., Sun, J., Chen, Y., Zong, M., Li, S. and Wang, Y. (2015) EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway. Oxidative Medicine and Cellular Longevity, 2015, Article ID: 214836. <br>https://doi.org/10.1155/2015/214836张姝萍, 王岳飞, 徐平. 茶多酚对动脉粥样硬化的预防作用与机理研究进展[J]. 茶叶科学, 2019, 39(3): 231-246.李元慈. 茶多酚对肝脏的保护作用研究[J]. 中国食物与营养, 2019, 25(9): 75-78.张勇, 李苗苗, 华田苗, 孙庆艳. 茶多酚对慢性酒精中毒大鼠肝损伤的保护作用[J]. 中国应用生理学杂志, 2018, 34(6): 481-484+529.陈武, 徐锦龙, 陈元娜. 茶多酚对染铅大鼠肝脏的保护作用[J]. 医药导报, 2012, 31(7): 849-851.高仁金, 陈小燕. 茶叶废料茶多酚的提取及其体外抗氧化性研究[J]. 山东化工, 2016, 45(20): 24-26.Maeda, K., Kuzuya, M., Cheng, X.W., Asai, T., Kanda, S., Tamaya-Mori, N., Iguchi, A., et al. (2003) Green Tea Catechins Inhibit the Cultured Smooth Muscle Cell Invasion through the Basement Barrier. Atherosclerosis, 166, 23-30.
<br>https://doi.org/10.1016/S0021-9150(02)00302-7李柯欣. 茶多酚的提取、抑菌作用与抑菌机理研究[D]: [硕士学位论文]. 成都: 西华大学, 2017.Arakawa, H., Maeda, M., Okubo, S. and Shimamura, T. (2004) Role of Hydrogen Peroxide in Bactericidal Action of Catechin. Biological and Pharmaceutical Bulletin, 27, 277-281. <br>https://doi.org/10.1248/bpb.27.277张杨波, 饶甜甜, 刘仲华. 茶多酚的抗癌作用机制及EGCG纳米载体技术研究进展[J]. 食品工业科技, 2019, 40(16): 343-348.Song, X., Du, J., Zhao, W. and Guo, Z. (2017) Epi-gallocatechin-3-Gallate (EGCG): Mechanisms and the Combined Applications. Combinatorial Chemistry & High Throughput Screening.
<br>https://doi.org/10.2174/1386207321666171218115850Kumazoe, M., Takai, M., Hiroi, S., Takeuchi, C., Ya-manouchi, M., Nojiri, T., Tachibana, H., et al. (2017) PDE3 Inhibitor and EGCG Combination Treatment Suppress Can-cer Stem Cell Properties in Pancreatic Ductal Adenocarcinoma. Scientific Reports, 7, Article No. 1917. <br>https://doi.org/10.1038/s41598-017-02162-9Zhou, C.G., Hui, L.M. and Luo, J.M. (2018) Epigallocatechin Gallate Inhibits the Proliferation and Induces Apoptosis of Multiple Myeloma Cells via Inactivating EZH2. European Re-view for Medical and Pharmacological Sciences, 22, 2093-2098.Hussain, S. (2017) Comparative Efficacy of Epi-gallocatechin-3-Gallate against H2O2-Induced ROS in Cervical Cancer Biopsies and HeLa Cell Lines. Contemporary Oncology (Pozn), 21, 209-212. <br>https://doi.org/10.5114/wo.2017.70110Kavanagh, K.T., Hafer, L.J., Kim, D.W., Mann, K.K., Sherr, D.H., Rogers, A.E. and Sonenshein, G.E. (2001) Green Tea Extracts Decrease Carcino-gen-Induced Mammary Tumor Burden in Rats and Rate of Breast Cancer Cell Proliferation in Culture. Journal of Cellu-lar Biochemistry, 82, 387-398. <br>https://doi.org/10.1002/jcb.1164王建华, 戈新, 张宝珣, 刘忠琛, 李培培, 江科. 茶多酚复合添加剂对肉猪肥育性能、胴体性状和肌肉品质的影响[J]. 畜牧与兽医, 2011, 43(1): 46-48.徐坤, 李明元, 马嫄. 茶多酚对生长育肥猪生长性能和肉质的影响研究[J]. 粮食与饲料工业, 2009(4): 43-44.严理, 薛菠, 刘龙洲, 李伟国, 田光明, 杨烨. 超微茶粉对断奶仔猪血清免疫及抗氧化性能的影响[J]. 长江大学学报(自科版), 2017, 14(10): 21-24+3.薛菠, 李楠洋, 汤雨凌, 罗静娴, 田光明, 杨烨. 超微茶粉对断奶仔猪肠道发育及抗氧化机能的影响[J]. 畜牧与兽医, 2017, 49(9): 53-56.张幸彦, 冯涛, 白佳桦, 许晓玲, 黄正, 韩向敏, 刘彦. 茶多酚对初产母猪繁殖性能和抗氧化性能的影响[J]. 甘肃农业大学学报, 2016, 51(1): 35-39.陈君君. 茶多酚对生长猪机体维生素E状态、抗氧化性能及肉质的影响[J]. 中国饲料, 2019(4): 55-58.谢东淇, 卫帅毅, 宋博宇, 梅军四, 王健, 万露, 杨公社, 胡建宏. 茶多酚对猪精液常温保存效果的影响[J]. 西北农林科技大学学报(自然科学版), 2017, 45(6): 23-29.赖兴富, 陈佳静, 郑江霞, 孙从佼, 徐桂云. 日粮中添加茶多酚对蛋鸡生产性能和蛋品质影响的Meta分析[J]. 中国家禽, 2019, 41(16): 58-64.和振东, 冯海涛. 茶与运动——茶多酚对运动员身体的调节作用[J]. 福建茶叶, 2016, 38(6): 26-27.张艳秋, 孟凡玲. 茶多酚的生物学效应及其在运动中的应用机制[J]. 山西师大体育学院学报, 2006(S1): 138-140.