高分子固载Lewis酸催化剂相比传统Lewis酸催化剂,在基本保留其原有催化活性、反应条件更温和等特点的同时,还具有对设备低腐蚀性、易于实现连续化、环境友好等显著优点,因而在医药化工领域具有十分广阔的产业化应用前景。本文利用一种固载FeCl
3催化剂,即将FeCl
3与聚苯乙烯反应制成负载型氯化铁催化剂(PS-FeCl
3),催化靛红、苯酚以及2-卤代吲哚化合物的多组分串联环化反应“一锅法”高效合成螺环苯并吡喃[2,3-b]吲哚类衍生物。
Polymer-supported Lewis acid catalysts is dominion over traditional ones in a number of aspects for instance; it retains its original catalytic activity, mild reaction conditions are required, which integrate remarkable advantages in catalyst regeneration, low corrosiveness of equipment, easy achievement of continuous production, environment-friendly aspects, etc. since there are great prospects of wide range of applications in the pharmaceutical and fine chemical industry. In this work, an immobilized solid Lewis acid catalyst (PS-FeCl
3) was prepared, which catalyzed the multi-component reaction casecade of isatin, phenol and 2-haloindole in one-pot manner to provide diverse spirooxindole-chromeno[2,3-b]indole derivatives with high efficiency.
路易斯酸,固载催化剂,三氯化铁,螺环苯并吡喃[23-b]吲哚,多组分串联反应, Lewis Acid Immobilized Solid Catalyst PS-FeCl3 Spirooxindole-Chromeno[23-b]Indole Multi-Component Reaction固载化FeCl3催化合成螺环苯并吡喃[2,3-b]吲哚类衍生物
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