罗汉果是中国传统的药食同源的药品,具有良好的药用价值和保健功能,而罗汉果多糖是罗汉果的重要活性成分之一,具有抗氧化、抗肿瘤和降血糖等生物活性。本文对近年来罗汉果多糖的药理方面的研究进行了综述,并展望了罗汉果多糖的药理研究发展趋势。 Momordica grosvenoriis a traditional Chinese medicine of the same origin of medicine and food, with good medicinal value and health care function, and Luo Han Guo polysaccharide is one of the important active ingredients, with antioxidant, anti-tumor and hypoglycemia biological activities. In this paper, the recent studies on the pharmacology of Fructus Momordicae polysaccharides were reviewed, and the development trend of pharmacological research on fructus Momordicae polysac-charides was prospected.
Research Progress on Pharmacological Action of Fructus Armandii Polysaccharide
Danling Sun,Yueyi Deng*
Medical College of Guilin, Guilin Guangxi
Received: Feb. 25th, 2021; accepted: Mar. 22nd, 2021; published: Mar. 29th, 2021
ABSTRACT
Momordica grosvenoriis a traditional Chinese medicine of the same origin of medicine and food, with good medicinal value and health care function, and Luo Han Guo polysaccharide is one of the important active ingredients, with antioxidant, anti-tumor and hypoglycemia biological activities. In this paper, the recent studies on the pharmacology of Fructus Momordicae polysaccharides were reviewed, and the development trend of pharmacological research on fructus Momordicae polysaccharides was prospected.
孙丹玲,邓月义. 罗汉果多糖药理作用研究进展Research Progress on Pharmacological Action of Fructus Armandii Polysaccharide[J]. 药物资讯, 2021, 10(02): 66-71. https://doi.org/10.12677/PI.2021.102009
参考文献References李俊, 黄艳, 何星存, 苏小建, 陈海燕, 廖日权. 罗汉果多糖的结构研究[J]. 食品工业科技, 2008, 29(8): 169-172.赵祥杰, 杨荣玲, 邝哲师, 叶明强, 罗国庆, 肖更生, 等. 植物来源多糖的研究进展[J]. 安徽农业科学, 2012, 40(35): 17016-17018.张彦民, 李宝才, 朱利平, 戴伟锋, 范家恒. 多糖化学及其生物活性研究进展[J]. 昆明理工大学学报, 2003, 28(3): 140-145, 149.刘婷, 周光明. 多糖的提取和分析方法[J]. 化工时刊, 2008, 22(3): 66-70.李俊, 黄锡山, 张艳军, 苏小建, 何星存. 超声波法提取罗汉果多糖的工艺研究[J]. 中药材, 2007, 30(4): 475-477.黄翠萍, 李俊, 刘庆业, 陆学文, 蒙爱萍, 朱圣军. 罗汉果多糖SGPS2的结构研究[J]. 中药材, 2010, 33(3): 376-379.李珊, 梁俭, 刘晓凤, 冼丽清. 罗汉果籽多糖的提取纯化及其抗氧化活性测试[J]. 粮食与油脂, 2020, 33(2):78-83.Hossen, M.A. and Sun, L.Q. (2006) Effects of Siraitia grosvenorii on Nasal and Scratching Behaviors in ICR Mice. International Journal of Chinese Medicine, 5, 294.Ling, M.A., Zhao, Y.N., Zhang, L., et al. (2018) Extraction and Purification of Polysaccharide from Selenium Contained Pleurotus os-treatus and Antioxidant Activity Assay. Food Research & Development, 39, 38-42.Wang, M., Song, Z.J., Ke, M.Z., Nong, F.L. and Wang, Q. (1994) Effects of Different Doses of Siraitia grosvenorii Swingle on the Immune Func-tion of Rats. Acta Academiae Medicinae Guangxi, 11, 408-410.张宏. 罗汉果的遗传毒性与胚胎发育毒性实验研究[D]: [硕士学位论文]. 遵义: 遵义医学院, 2011.Suzuki, Y.A., Tomoda, M., Murata, Y., Inui, H., Sugiura, M. and Nakano, Y. (2007) Antidiabetic Effect of Long-Term Supplementation with Siraitia grosvenorii on the Sponta-neously Diabetic Goto-Kakizaki Rat. British Journal of Nutrition, 97, 770-775. <br>https://doi.org/10.1017/S0007114507381300Ye, M. and Zhou, Y. (2008) Preliminary Research on Antibacte-rial Activity of the Ethanol Extracts from Momordica grosvenorii Leaf and Stem. J Mount Agric Biol, 27, 42-46.Yao, J.W., Tang, H., Shen, W.H., et al. (2007) The Observation on Impacts of the Different Dosage of Luo Han Guo on Physiological Function in Mice by Training of Increasing Intensity. Liaoning Sport Science and Technology, 29, 24-26.Yao, J.W., Tang, H., Zhou, L., Shen, W.H., Li, Y.X., Tian, X.Z., et al. (2008) Effect of Siraitia grosvenorii Extract on the Movement Endurance and Liver Tissue Injury of Mice. Chinese Journal of Sports Medicine, 27, 221-223.Chen, M. (2008) The Experimental Study of Protective Effects of Anti-Oxidation Damage on Some Tissues of the Flavones in Siraitia grosvenorii Leaf on Exhaustive Swimming in Rat. Master’s Degree Thesis, Guangxi Normal University, Guilin.Wang, Q., Li, A.Y., Li, X.P., et al. (1999) Pharmacological Effects of S. grosvenorii Fruit. China Journal of Chinese Materia, 24, 425-428.Pan, M.H., Yang, J.R., Tasi, M.L., Sang, S. and Ho, C.-T. (2009) Anti-Inflammatory Effect of Momordica grosvenorii Swingle Extract through Suppressed LPS-Induced Upregu-lation of INOS and COX-2 in Murine Macrophages. Journal of Functional Foods, 1, 145-152. <br>https://doi.org/10.1016/j.jff.2009.01.003Qi, X.Y., Chen, W.J., Song, Y.F. and Xie, B.J. (2003) Hypoglyce-mic Effect of Siraitia grosvenorii Extract on Diabetic Mice. Chinese Journal of Public Health, 19, 1226-1227.Wan, Y.J., Wu, J.L. and Wu, Q.P. (2016) A Review of the Hypoglycemic Activity of Siraitia grosvenorii. Food Research and Development, 37, 188-191.Maria, A.H. and Yoshifumi, S. (2005) Effect of Lo Han Kuo (Siraitia grosvenorii Swingle) on Nasal Rubbing and Scratching Behavior in ICR Mice. Biological & Pharmaceutical Bulletin, 28, 238-241.Lin, Y.W. and Chen, X.Y. (2008) Influence of Siraitia grosvenorii on the Growth and Conservation of Lactic Acid Bacteria. Journal of Food Science and Technology, No. 4, 150-153.Wang, C.Q. and Hu, S.L. (2012) Study on the Protection Effect and Mechanism of Total Flavones from Siraitia grosvenorii Leaf on the Endothelial Cell Injury Induced by Metal Ion. Journal of Yangtze University, 9, 1-2, 9.