MiT/TFE家族包括转录因子EB (Transcription factor EB, TFEB)、TFE3、TFEC和MITF,其中TFEB在调控细胞能量平衡和自噬溶酶体生物发生中发挥主导作用。自噬溶酶体途径是吞噬并清除废旧蛋白及细胞器从而维持机体平衡的重要途径,而越来越多的研究表明自噬溶酶体在调节机体炎症免疫反应中也具有重要作用。TFEB作为自噬溶酶体生物发生的重要调节因子,可通过影响溶酶体的发生从而调控机体炎症免疫反应。新近研究表明,TFEB还能直接通过调控免疫相关基因的转录,从而调控机体免疫反应。我们将通过对TFEB在自噬与炎症反应的作用进行讨论,为进一步研究TFEB在炎症免疫反应中的作用奠定基础。
The MiT/TFE family includes transcription factor EB (TFEB), TFE3, TFEC and MITF, among which TFEB plays a leading role in regulating cell energy balance and autophagolysosome biogenesis. The autophagolysosome pathway is an important way for waste proteins and organelles clearing, and more and more studies show that autophagolysosomes also play an important role in regulating the body’s inflammatory immune response. TFEB, as an important regulator of autophagolysosome biogenesis, can regulate the inflammatory immune response of the body by affecting the occurrence of lysosomes. Recent studies have shown that TFEB can also directly regulate the immune response of the body by regulating the transcription of immune-related genes. We are going to discuss the role of TFEB in autophagy and inflammatory response to lay the foundation for further research on the role of TFEB in inflammatory immune response.
Research Progress of Transcription Factor EB in Immune Response
Jiajian Yu, Deqing Fan*
Department of Hepatobiliary Surgery, Chongqing Fuling Central Hospital, Chongqing
Received: May 10th, 2021; accepted: May 29th, 2021; published: Jun. 11th, 2021
ABSTRACT
The MiT/TFE family includes transcription factor EB (TFEB), TFE3, TFEC and MITF, among which TFEB plays a leading role in regulating cell energy balance and autophagolysosome biogenesis. The autophagolysosome pathway is an important way for waste proteins and organelles clearing, and more and more studies show that autophagolysosomes also play an important role in regulating the body’s inflammatory immune response. TFEB, as an important regulator of autophagolysosome biogenesis, can regulate the inflammatory immune response of the body by affecting the occurrence of lysosomes. Recent studies have shown that TFEB can also directly regulate the immune response of the body by regulating the transcription of immune-related genes. We are going to discuss the role of TFEB in autophagy and inflammatory response to lay the foundation for further research on the role of TFEB in inflammatory immune response.
余家建,范德庆. 转录因子EB在机体免疫反应中的研究进展Research Progress of Transcription Factor EB in Immune Response[J]. 临床医学进展, 2021, 11(06): 2639-2644. https://doi.org/10.12677/ACM.2021.116381
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