慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)是一种以持续的呼吸道症状和气流受限为特征,可以预防和治疗的疾病。其具有高发病率、高伤残率、高死亡的特点。COPD的发病机制尚未完全明确,而目前研究表明炎性反应机制仍是疾病进展的核心机制,因此抗炎治疗是关键。大环内酯类药物(Macrolides,简称MA)的抗炎作用逐步得到证实并应用于这类疾病的治疗,本文就MA的生物学特性及其在慢性阻塞性肺疾病稳定期中的疗效做一综述。
Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent respiratory symptoms and airflow limitation, which can be prevented and treated. It has the characteristics of high morbidity, disability, and death. The pathogenesis of COPD has not yet been fully clarified, and current studies have shown that the inflammatory response mechanism is still the core mechanism of disease progression, so anti-inflammatory therapy is the key. The anti-inflammatory effects of macrolides (Macrolides abbreviated as MA) have been gradually confirmed and applied to the treatment of such diseases. This article reviews the biological characteristics of MA and its efficacy in the stable phase of chronic obstructive pulmonary disease.
Research Progress of Anti-Inflammatory Effects of Macrolides on Chronic Obstructive Pulmonary Disease
Man Zhang, Weimin Sun
Yan’an University Affiliated Hospital, Yan’an Shaanxi
Received: May 10th, 2021; accepted: May 29th, 2021; published: Jun. 11th, 2021
ABSTRACT
Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent respiratory symptoms and airflow limitation, which can be prevented and treated. It has the characteristics of high morbidity, disability, and death. The pathogenesis of COPD has not yet been fully clarified, and current studies have shown that the inflammatory response mechanism is still the core mechanism of disease progression, so anti-inflammatory therapy is the key. The anti-inflammatory effects of macrolides (Macrolides abbreviated as MA) have been gradually confirmed and applied to the treatment of such diseases. This article reviews the biological characteristics of MA and its efficacy in the stable phase of chronic obstructive pulmonary disease.
张 曼,孙伟民. 大环内酯类药物对慢性阻塞性肺疾病稳定期抗炎疗效研究进展Research Progress of Anti-Inflammatory Effects of Macrolides on Chronic Obstructive Pulmonary Disease[J]. 临床医学进展, 2021, 11(06): 2645-2649. https://doi.org/10.12677/ACM.2021.116382
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