丙烯酰胺是一种有机化合物, 可通过消化道、呼吸道、皮肤黏膜等途径被人体吸收,具有潜在致癌性、神经、遗传、生殖发育毒性等。无论植物药还是动物药,中药材来源自然,成分复杂,富含氨基酸、多肽、蛋白质等氨基类化合物与还原糖等羰基类化合物,并且几乎大部分中药材都需要经过高温炮制后才能使用,这两个条件的共同作用导致中药材在加工过程中存在丙烯酰胺的污染风险。因此研究丙烯酰胺的污染状况和检测方法,对中药材的安全风险控制、提高中药材的安全质量和用药安全水平具有科学指导意义。本文对现有的丙烯酰胺的前处理和仪器测定方法予以概括和总结,并对未来中药材现代化检测前景进行展望,以期为中药材的科学安全加工提供参考,进一步提高中药饮片质量,保障用药者安全。 Acrylamide, an organic compound that can be absorbed by the body through the digestive tract, respiratory tract, skin and mucous membranes, has potential carcinogenicity, neurological toxicity, genetic toxicity, reproductive and developmental toxicity and so on. Both plant medicine and animal drugs, Chinese traditional medicine comes originally from Nature and is rich in amino compounds such as amino acids, peptides, proteins and some carbonyl compounds, reductive sugars included. Simultaneously, almost all Chinese traditional medicine needs to be processed at a high temperature before use. The combination of two aforementioned conditions results in the risk of acrylamide in thermally processed Chinese traditional medicine. Therefore, it is of significant guidance for risk assessment, quality assurance and security of medication to study the determination of acrylamide on the basis of the present Contamination status. In this paper, the existing methods of pretreatment and determination of acrylamide are summarized and the blueprint for modern detection in Chinese traditional medicine is painted, so as to provide reference for scientific and safe processing of Chinese traditional medicine, to improve the quality of Chinese herbal decoction pieces further and to ensure the security of drug users.
中药材,丙烯酰胺,污染状况,前处理方法,检测方法, Chinese Traditional Medicines Acrylamide Contamination Status Pretreatment Determination摘要
Acrylamide, an organic compound that can be absorbed by the body through the digestive tract, respiratory tract, skin and mucous membranes, has potential carcinogenicity, neurological toxicity, genetic toxicity, reproductive and developmental toxicity and so on. Both plant medicine and animal drugs, Chinese traditional medicine comes originally from Nature and is rich in amino compounds such as amino acids, peptides, proteins and some carbonyl compounds, reductive sugars included. Simultaneously, almost all Chinese traditional medicine needs to be processed at a high temperature before use. The combination of two aforementioned conditions results in the risk of acrylamide in thermally processed Chinese traditional medicine. Therefore, it is of significant guidance for risk assessment, quality assurance and security of medication to study the determination of acrylamide on the basis of the present Contamination status. In this paper, the existing methods of pretreatment and determination of acrylamide are summarized and the blueprint for modern detection in Chinese traditional medicine is painted, so as to provide reference for scientific and safe processing of Chinese traditional medicine, to improve the quality of Chinese herbal decoction pieces further and to ensure the security of drug users.
Keywords:Chinese Traditional Medicines, Acrylamide, Contamination Status, Pretreatment, Determination
樊 敏,朱炳祺. 高温炮制中药材中丙烯酰胺污染状况及检测方法的研究进展Contamination Status and Determination of Acrylamide in Thermally Processed Chinese Traditional Medicine[J]. 药物资讯, 2021, 10(04): 173-186. https://doi.org/10.12677/PI.2021.104023
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