缝合线、缝合钉是当前外科手术中实现伤口闭合或植入物固定的常用手段,然而,这些侵入性技术引起的疼痛和不适,导致迫切需要开发用于外科手术的组织粘合剂。本文主要介绍了组织粘合剂的设计标准,以及现有组织粘合剂的种类和应用。目前,生物类(如纤维蛋白胶)、合成类(如氰基丙烯酸酯胶)组织粘合剂已在临床上有广泛的运用,但它们存在的固有缺点驱使着人们进一步开发性能更为优良的组织黏合剂。众多的研究团队致力于化学修饰天然多肽/蛋白/多糖开发半合成类组织粘合剂。尽管这些研究工作取得了一定进展,但尚且缺少长期研究和临床试验。此外,开发新型多功能粘合剂,在满足粘附生物组织的同时,降低感染率,提高治疗药物的功效等等,已然成为了组织粘合剂研究的新热点。这些新功能的结合将极大地增强组织粘合剂的效用并扩大其生物医学应用,是组织粘合剂研究开发的新趋势。
Sutures and staples are common methods for wound closure or implant fixation in current surgical operations. However, the pain and discomfort caused by these invasive techniques have led to an urgent need to develop tissue adhesives for surgical operations. This article mainly introduces the design standards of tissue adhesives, as well as the types and applications of existing tissue adhesives. At present, biological (e.g. fibrin glue) and synthetic (e.g. cyanoacrylate glue) tissue adhesives have been widely used clinically, but their inherent shortcomings drive people to further develop better performance Tissue adhesive. Numerous research teams are committed to chemically modifying natural peptides/proteins/polysaccharides to develop semi-synthetic tissue adhesives. Although some progress has been made in these researches, there is still a lack of long-term research and clinical trials. In addition, the development of new multifunctional adhesives, which can reduce the infection rate or improve the efficacy of therapeutic drugs and so on, while satisfying the adhesion of biological tissues, has become a new hot spot in the research of tissue adhesives. The combination of these new functions will greatly enhance the effectiveness of tissue adhesives and expand their biomedical applications, which is a new trend in the research and development of tissue adhesives.
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong Jiangsu
Sutures and staples are common methods for wound closure or implant fixation in current surgical operations. However, the pain and discomfort caused by these invasive techniques have led to an urgent need to develop tissue adhesives for surgical operations. This article mainly introduces the design standards of tissue adhesives, as well as the types and applications of existing tissue adhesives. At present, biological (e.g. fibrin glue) and synthetic (e.g. cyanoacrylate glue) tissue adhesives have been widely used clinically, but their inherent shortcomings drive people to further develop better performance Tissue adhesive. Numerous research teams are committed to chemically modifying natural peptides/proteins/polysaccharides to develop semi-synthetic tissue adhesives. Although some progress has been made in these researches, there is still a lack of long-term research and clinical trials. In addition, the development of new multifunctional adhesives, which can reduce the infection rate or improve the efficacy of therapeutic drugs and so on, while satisfying the adhesion of biological tissues, has become a new hot spot in the research of tissue adhesives. The combination of these new functions will greatly enhance the effectiveness of tissue adhesives and expand their biomedical applications, which is a new trend in the research and development of tissue adhesives.
席夫碱反应( R 2 C = O + R ′ NH 2 → R 2 C = N R ′ + H 2 O )是胺和醛基之间温和条件下发生的,交联成胶的同时,也是与组织间共价交联形成粘附的原因(见图2)。基于这一概念,Mo团队通过席夫碱反应将醛官能团化的藻酸盐与胺官能团化的明胶交联,从而开发了一种粘合水凝胶。猪皮肤上的最大粘附强度约为11.51 ± 1.3 kPa [41]。
汤晓璇,顾心逸,陈晓莉,凌 珏,杨宇民. 水凝胶组织粘合剂的研究及进展 Research Progress of Hydrogels in Tissue Adhesive[J]. 分析化学进展, 2021, 11(03): 99-107. https://doi.org/10.12677/AAC.2021.113011
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