神经、精神类疾病、外科损伤、肿瘤以及衰老均会导致记忆、注意力、执行、视空间、社会认知等认知障碍,针对这些疾病的认知功能的评价,临床上应用的各种量表如简明精神状态量表(Mini-mental State Examination, MMSE)、蒙特利尔认知评估量表(Montreal Cognitive Assessment, MoCA)等,能够更简单快速的评价患者的情况。近年来,随着计算机神经心理评估系统的发展,剑桥神经心理自动化成套测试(CANTAB)可能是最完善和最有效的计算机神经心理测试系统,被广泛用于评估各种认知障碍疾病。对认知状态进行追踪观察,有助于对疾病的诊断及康复措施的制定治疗效果的判断,该综述以期利用CANTAB的优势为临床评估提供选择,进一步完善认知障碍疾病的诊断体系,对认知障碍疾病的预防和治疗提供新的发展契机。
Neurological, psychiatric diseases, surgical injuries, tumors and aging all lead to cognitive impairments such as memory, attention, executive, visuospatial and social cognition. For the evaluation of cognitive function of these diseases, various scales such as the Concise Mental State Scale (MMSE), Montreal Cognitive Assessment Scale (MoCA) and so on are used clinically, can easily and quickly evaluate patients’ conditions. With the development of computerized neuropsychological assessment systems, the Cambridge Automated Neuropsychological Test (CANTAB) is probably the most complete and effective computerized neuropsychological testing system, which is widely used to evaluate various cognitive disorders. The follow-up observation of cognitive status is conducive to the diagnosis of diseases and the development of rehabilitation measures to judge the therapeutic effect. This review aims to make use of the advantages of CANTAB to provide options for clinical evaluation, further improve the diagnostic system of cognitive disorders, and provide new development opportunities for the prevention and treatment of cognitive disorders.
剑桥神经心理自动化成套测试,认知功能评估,认知障碍, Cambridge Neuropsychological Automated Test Cognitive Function Assessment Cognitive
Impairment摘要
神经、精神类疾病、外科损伤、肿瘤以及衰老均会导致记忆、注意力、执行、视空间、社会认知等认知障碍,针对这些疾病的认知功能的评价,临床上应用的各种量表如简明精神状态量表(Mini-mental State Examination, MMSE)、蒙特利尔认知评估量表(Montreal Cognitive Assessment, MoCA)等,能够更简单快速的评价患者的情况。近年来,随着计算机神经心理评估系统的发展,剑桥神经心理自动化成套测试(CANTAB)可能是最完善和最有效的计算机神经心理测试系统,被广泛用于评估各种认知障碍疾病。对认知状态进行追踪观察,有助于对疾病的诊断及康复措施的制定治疗效果的判断,该综述以期利用CANTAB的优势为临床评估提供选择,进一步完善认知障碍疾病的诊断体系,对认知障碍疾病的预防和治疗提供新的发展契机。
关键词
剑桥神经心理自动化成套测试,认知功能评估,认知障碍
Application and Research Progress of Cambridge Neuropsychological Automated Test in Cognitive Disorders
Xiuxiu Bai1, Haihua Bao2
1Graduate School of Qinghai University, Xining Qinghai
2Image Center of Affiliated Hospital of Qinghai University, Xining Qinghai
Neurological, psychiatric diseases, surgical injuries, tumors and aging all lead to cognitive impairments such as memory, attention, executive, visuospatial and social cognition. For the evaluation of cognitive function of these diseases, various scales such as the Concise Mental State Scale (MMSE), Montreal Cognitive Assessment Scale (MoCA) and so on are used clinically, can easily and quickly evaluate patients’ conditions. With the development of computerized neuropsychological assessment systems, the Cambridge Automated Neuropsychological Test (CANTAB) is probably the most complete and effective computerized neuropsychological testing system, which is widely used to evaluate various cognitive disorders. The follow-up observation of cognitive status is conducive to the diagnosis of diseases and the development of rehabilitation measures to judge the therapeutic effect. This review aims to make use of the advantages of CANTAB to provide options for clinical evaluation, further improve the diagnostic system of cognitive disorders, and provide new development opportunities for the prevention and treatment of cognitive disorders.
Keywords:Cambridge Neuropsychological Automated Test, Cognitive Function Assessment, Cognitive Impairment
白秀秀,鲍海华. 剑桥神经心理自动化测试在认知障碍疾病中的应用与研究进展Application and Research Progress of Cambridge Neuropsychological Automated Test in Cognitive Disorders[J]. 临床医学进展, 2021, 11(12): 6117-6122. https://doi.org/10.12677/ACM.2021.1112907
参考文献ReferencesHodges, J.R. 临床神经心理学认知评估手册[M]. 第2版. 武汉: 华中科技大学出版社, 2012: 178-180.Sahakian, B.J. and Owen, A.M. (1992) Computerized Assessment in Neuropsychiatry Using CANTAB: Discussion Paper. Journal of the Royal Society of Medicine, 85, 399-402.Sahakian, B.J., Morris, R.G., Evenden, J.L., et al. (1988) A Comparative Study of Visuospatial Memory and Learning in Alzheimer-Type Dementia and Parkinson’s Disease. Brain, 111, 695-718. <br>https://doi.org/10.1093/brain/111.3.695Trevor, W. (2011) Robbins: Award for Distinguished Scientific Contributions. American Psychologist, 66, 665-668.
<br>https://doi.org/10.1037/a0025179Kim, H.S., An, Y.M., Kwon, J.S., et al. (2014) A Preliminary Validity Study of the Cambridge Neuropsychological Test Automated Battery for the Assessment of Executive Function in Schizophrenia and Bipolar Disorder. Psychiatry Investigation, 11, 394-401. <br>https://doi.org/10.4306/pi.2014.11.4.394Luciana, M. and Nelson, C.A. (2002) Assessment of Neuropsychological Function through Use of the Cambridge Neuropsychological Testing Automated Battery: Performance in 4- to 12-Year-Old Children. Developmental Neuropsychology, 22, 595-624. <br>https://doi.org/10.1207/S15326942DN2203_3Robbins, T.W., James, M., Owen, A.M., et al. (1994) Cambridge Neuropsychological Test Automated Battery (CANTAB): A Factor Analytic Study of a Large Sample of Normal Elderly Volunteers. Dementia, 5, 266-281.
<br>https://doi.org/10.1159/000106735Cacciamani, F., Salvadori, N., Eusebi, P., et al. (2018) Evidence of Practice Effect in CANTAB Spatial Working Memory Test in a Cohort of Patients with Mild Cognitive Impairment. Applied Neuropsychology: Adult, 25, 237-248.
<br>https://doi.org/10.1080/23279095.2017.1286346Barnett, J.H., Robbins, T.W., Leeson, V.C., et al. (2010) Assessing Cognitive Function in Clinical Trials of Schizophrenia. Neuroscience & Biobehavioral Reviews, 34, 1161-1177. <br>https://doi.org/10.1016/j.neubiorev.2010.01.012Evenden, J., Morris, R., Owen, A., et al. (2013) CANTABeclipseTM Test Administration Guide (Manual ver.). Cambridge Cognition Limited, Cambridge.Robbins, T.W., James, M., Owen, A.M., et al. (1998) A Study of Performance on Tests from the CANTAB Battery Sensitive to Frontal Lobe Dysfunction in a Large Sample of Normal Volunteers: Implications for Theories of Executive Functioning and Cognitive Aging. Journal of the International Neuropsychological Society, 4, 474-490.
<br>https://doi.org/10.1017/S1355617798455073Cambridge Cognition Ltd. (2013) CANTAB® Normative Data. Cambridge Cognition Ltd., Cambridge.Juncos-Rabadan, O., Pereiro, A.X., Facal, D., et al. (2014) Do the Cambridge Neuropsychological Test Automated Battery Episodic Memory Measures Discriminate Amnestic Mild Cognitive Impairment? International Journal of Geriatric Psychiatry, 29, 602-609. <br>https://doi.org/10.1002/gps.4042李雪艳, 代杰, 赵沙沙, 等. 简易认知量表在门诊快速识别轻度认知障碍患者中的价值[J]. 中国老年学杂志, 2019, 39(5): 1128-1130.刘忠玲, 朱香玲, 李安民. 北京版蒙特利尔认知评估量表在白银市地区筛查轻度认知功能障碍的分界值[J]. 中国老年学杂志, 2019, 39(17): 4271-4274.Smith, P.J., Need, A.C., Cirulli, E.T., et al. (2013) A Comparison of the Cambridge Automated Neuropsychological Test Battery (CANTAB) with “Traditional” Neuropsychological Testing Instruments. Journal of Clinical and Experimental Neuropsychology, 35, 319-328. <br>https://doi.org/10.1080/13803395.2013.771618Schulz-Heik, R.J., Fahimi, A., Durazzo, T.C., Friedman, M. and Bayley, P.J. (2020) Evaluation of Adding the CANTAB Computerized Neuropsychological Assessment Battery to a Traditional Battery in a Tertiary Care Center for Veterans. Applied Neuropsychology: Adult, 27, 256-266. <br>https://doi.org/10.1080/23279095.2018.1534735Mitchell, A.J. and Shiri-Feshki, M. (2009) Rate of Progression of Mild Cognitive Impairment to Dementia-Meta-Analysis of 41 Robust Inception Cohort Studies. Acta Psychiatrica Scandinavica, 119, 252-265.
<br>https://doi.org/10.1111/j.1600-0447.2008.01326.xLowe, C. and Rabbitt, P. (1998) Test/Re-Test Reliability of the CANTAB and ISPOCD Neuropsychological Batteries: Theoretical and Practical Issues. Neuropsychologia, 36, 915-923. <br>https://doi.org/10.1016/S0028-3932(98)00036-0Juncos-Rabadan, O., Pereiro, A.X., Facal, D., et al. (2014) Do the Cambridge Neuropsychological Test Automated Battery Episodic Memory Measures Discriminate Amnestic Mild Cognitive Impairment? International Journal of Geriatric Psychiatry, 29, 602-609. <br>https://doi.org/10.1002/gps.4042Nathan, P.J., Lim, Y.Y., Abbott, R., Galluzzi, S., et al. (2017) Association between CSF Biomarkers, Hippocampal Volume and Cognitive Function in Patients with Amnestic Mild Cognitive Impairment (MCI). Neurobiology of Aging, 53, 1-10. <br>https://doi.org/10.1016/j.neurobiolaging.2017.01.013(2000) Clinical Practice Guideline: Diagnosis and Evaluation of the Child with Attention-Deficit/Hyperactivity Disorder. American Academy of Pediatrics. Pediatrics, 105, 1158-1170. <br>https://doi.org/10.1542/peds.105.5.1158Claesdotter, E., Cervin, M., Åkerlund, S., et al. (2018) The Effects of ADHD on Cognitive Performance. Nordic Journal of Psychiatry, 72, 158-163. <br>https://doi.org/10.1080/08039488.2017.1402951Gau, S.S. and Shang, C.Y. (2010) Executive Functions as Endophenotypes in ADHD: Evidence from the Cambridge Neuropsychological Test Battery (CANTAB). Journal of Child Psychology and Psychiatry, 51, 838-849.
<br>https://doi.org/10.1111/j.1469-7610.2010.02215.x高晓雷, 孙敏, 任晓飞, 等. 视觉记忆的海拔效应——来自配对联想学习任务的证据[J]. 高原科学研究, 2018, 2(1): 77-82.何明丽. 3TMRI对慢性高原病患者脑结构与认知功能的对照研究[D]: [硕士学位论文]. 西宁: 青海大学, 2013.Joyce, E.M., Hutton, S.B., Mutsatsa, S.H., et al. (2005) Cognitive Heterogeneity in First-Episode Schizophrenia. The British Journal of Psychiatry, 187, 516-522. <br>https://doi.org/10.1192/bjp.187.6.516Wood, S.J., Pantelis, C., Proffitt, T., Phillips, L.J., Stuart, G.W., Buchanan, J.A., et al. (2003) Spatial Working Memory Ability Is a Marker of Risk-for-Psychosis. Psychological Medicine, 33, 1239-1247.
<br>https://doi.org/10.1017/S0033291703008067Bakos, D.S., Denburg, N., Fonseca, R.P. and de Mattos Pimenta Parente, M.A. (2010) A Cultural Study on Decision Making: Performance Differences on the Iowa Gambling Task between Selected Groups of Brazilians and Americans. Psychology & Neuroscience, 3, 101-107. <br>https://doi.org/10.3922/j.psns.2010.1.013De Luca, C.R., Wood, S.J., Anderson, V., Buchanan, J.A., Proffitt, T.M., Mahony, K. and Pantelis, C. (2003) Normative Data from the Cantab. I: Development of Executive Function over the Life-Span. Journal of Clinical and Experimental Neuropsychology, 25, 242-254.Dassanayake, T.L. and Ariyasinghe, D.I. (2019) Sex-, Age-, and Education-Adjusted Norms for Cambridge Neuropsychological Test Automated Battery in Literate Sri Lankan Adults. The Clinical Neuropsychologist, 33, 106-124.