左西孟旦作为一种新型正性肌力药物,通过钙增敏作用增强心肌收缩力(强心的同时不增加心肌耗氧量),线粒体ATP敏感的K
+通道激活可起到保护心肌的作用,且其能激活血管平滑肌K
ATP通道,舒张全身动静脉,降低心脏前后负荷、肺血管阻力,改善多器官微循环。左西孟旦的以上作用特点对心脏PCI手术成功率及预后意义重大,本文就左西孟旦在心脏PCI围术期中的临床应用及其改善血流动力学、肺循环、肾功能、减轻术后并发症的临床研究进展作一综述。
Levosimendan, as a new positive inotropic drug, enhances myocardial contractility through calcium sensitization (strengthening the heart without increasing myocardial oxygen consumption). The activation of mitochondrial ATP sensitive K
+ channel can protect the myocardium, and it can activate the K
ATP channel of vascular smooth muscle, relax systemic arteries and veins, reduce the anterior and posterior load of heart and pulmonary vascular resistance, and improve multi-organ microcirculation. The above characteristics of levosimendan are of great significance to the success rate and prognosis of cardiac PCI. This paper reviews the clinical application of levosimendan in the perioperative period of cardiac PCI and its clinical research progress in improving hemodynamics, pulmonary circulation, renal function and reducing postoperative complications.
左西孟旦,围术期,心脏PCI,并发症, Levosimendan Perioperative Period Cardiac PCI Complication摘要
Levosimendan, as a new positive inotropic drug, enhances myocardial contractility through calcium sensitization (strengthening the heart without increasing myocardial oxygen consumption). The activation of mitochondrial ATP sensitive K+ channel can protect the myocardium, and it can activate the KATP channel of vascular smooth muscle, relax systemic arteries and veins, reduce the anterior and posterior load of heart and pulmonary vascular resistance, and improve multi-organ microcirculation. The above characteristics of levosimendan are of great significance to the success rate and prognosis of cardiac PCI. This paper reviews the clinical application of levosimendan in the perioperative period of cardiac PCI and its clinical research progress in improving hemodynamics, pulmonary circulation, renal function and reducing postoperative complications.
贺 筱,吴倩倩,耿 强,王正忠. 左西孟旦在心脏PCI围术期的应用进展Application Progress of Levosimendan in Perioperative Period of Cardiac PCI[J]. 临床医学进展, 2022, 12(01): 62-66. https://doi.org/10.12677/ACM.2022.121011
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