p53正向细胞凋亡调控因子(p53 up-regulated modulator of apoptosis, PUMA)在许多疾病的发生发展中发挥着至关重要的作用,其调控机制主要为转录水平的调控(p53依赖/非依赖途径)及翻译后磷酸化调控机制,相关microRNA-PUMA信号通路的发现,不仅为肿瘤性疾病的治疗提供了新依据,也为许多非肿瘤性疾病的治疗提供了新思路,如老年性急性心肌梗死、心脏瓣膜病、神经元退行性变、血脑屏障等疾病近年来有了新的突破,甚至有望成为疾病新的预测分子。本文主要从microRNA-PUMA相关通路的发现就近年来在非肿瘤性疾病中的研究作一综述。
p53 up-regulated modulator of apoptosis (PUMA) plays an important role in the development of many diseases. Its regulatory mechanisms include transcriptional regulation (p53-dependent/ non-dependent pathway) and post-translational phosphorylation. The discovery of related microRNA-PUMa signaling pathway not only provides a new basis for the treatment of neoplastic diseases, but also provides a new idea for the treatment of many non-neoplastic diseases: for example, senile acute myocardial infarction, heart valvular disease, neuronal degeneration, blood-brain barrier and other diseases have made new breakthroughs in recent years, and are even expected to become new predictive molecules of diseases. In this paper, the findings of microRNA-PUMA related pathways in non-neoplastic diseases in recent years are reviewed.
p53正向细胞凋亡调控因子,microRNA,非肿瘤性疾病, p53 Up-Regulated Modulator of Apoptosis microRNA Non-Neoplastic Diseases摘要
p53正向细胞凋亡调控因子(p53 up-regulated modulator of apoptosis, PUMA)在许多疾病的发生发展中发挥着至关重要的作用,其调控机制主要为转录水平的调控(p53依赖/非依赖途径)及翻译后磷酸化调控机制,相关microRNA-PUMA信号通路的发现,不仅为肿瘤性疾病的治疗提供了新依据,也为许多非肿瘤性疾病的治疗提供了新思路,如老年性急性心肌梗死、心脏瓣膜病、神经元退行性变、血脑屏障等疾病近年来有了新的突破,甚至有望成为疾病新的预测分子。本文主要从microRNA-PUMA相关通路的发现就近年来在非肿瘤性疾病中的研究作一综述。
关键词
p53正向细胞凋亡调控因子,microRNA,非肿瘤性疾病
Research Progress in the Regulation of Puma Expression by microRNA in Non-Neoplastic Diseases
Wangzhao Tian1, Yongfu Lu2, Xuehong Wang2
1Qinghai University, Xining Qinghai
2The Affiliated Hospital of Qinghai University, Xining Qinghai
p53 up-regulated modulator of apoptosis (PUMA) plays an important role in the development of many diseases. Its regulatory mechanisms include transcriptional regulation (p53-dependent/ non-dependent pathway) and post-translational phosphorylation. The discovery of related microRNA-PUMa signaling pathway not only provides a new basis for the treatment of neoplastic diseases, but also provides a new idea for the treatment of many non-neoplastic diseases: for example, senile acute myocardial infarction, heart valvular disease, neuronal degeneration, blood-brain barrier and other diseases have made new breakthroughs in recent years, and are even expected to become new predictive molecules of diseases. In this paper, the findings of microRNA-PUMA related pathways in non-neoplastic diseases in recent years are reviewed.
Keywords:p53 Up-Regulated Modulator of Apoptosis, microRNA, Non-Neoplastic Diseases
田王钊,芦永福,王学红. microRNA-PUMA信号通路在非肿瘤性疾病中的研究进展Research Progress in the Regulation of Puma Expression by microRNA in Non-Neoplastic Diseases[J]. 临床医学进展, 2022, 12(01): 709-715. https://doi.org/10.12677/ACM.2022.121104
参考文献ReferencesGarrison, S.P., Phillips, D.C., Jeffers, J.R., Chipuk, J.E., Parsons, M.J., Rehg, J.E., Opferman, J.T., Green, D.R. and Zambetti, G.P. (2012) Genetically Defining the Mechanism of Puma- and Bim-Induced Apoptosis. Cell Death & Differentiation, 19, 642-649. <br>https://doi.org/10.1038/cdd.2011.136Liu, Z., Sun, J., Liu, B., et al. (2018) MiRNA-222 Promotes Liver Cancer Cell Proliferation, Migration and Invasion and Inhibits Apoptosis by Targeting BBC3. International Journal of Molecular Medicine, 42, 141-148.
<br>https://doi.org/10.3892/ijmm.2018.3637Adams, J.M. and Cory, S. (2007) The Bcl-2 Apoptotic Switch in Cancer Development and Therapy. Oncogene, 26, 1324-1337. <br>https://doi.org/10.1038/sj.onc.1210220Yu, J., Zhang, L., Hwang, P.M., Kinzler, K.W. and Vogelstein, B. (2001) PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells. Molecular Cell, 7, 673-682. <br>https://doi.org/10.1016/S1097-2765(01)00213-1Adams, J.M. and Cory, S. (1998) The Bcl-2 Protein Family: Arbiters of Cell Survival. Science, 281, 1322-1326.
<br>https://doi.org/10.1126/science.281.5381.1322Yu, J., Wang, Z., Kinzler, K.W., et al. (2003) PUMA Mediates the Apoptotic Response to p53 in Colorectal Cancer Cells. Proceedings of the National Academy of Sciences of the United States of America, 100, 1931-1936.
<br>https://doi.org/10.1073/pnas.2627984100Cartron, P.F., Gallenne, T., Bougras, G., et al. (2004) The First Alpha Helix of Bax Plays a Necessary Role in Its Ligand-Induced Activation by the BH3-Only Proteins Bid and PUMA. Molecular Cell, 16, 807-818.
<br>https://doi.org/10.1016/j.molcel.2004.10.028Chipuk, J.E. and Green, D.R. (2009) PUMA Cooperates with Direct Activator Proteins to Promote Mitochondrial Outer Membrane Permeabilization and Apoptosis. Cell Cycle, 8, 2692-2696. <br>https://doi.org/10.4161/cc.8.17.9412张念平, 刘浩, 龙大宏. microRNA对干细胞调控作用的研究进展[J]. 中国老年学杂志, 2020, 40(8): 1781-1784.Feng, W. and Feng, Y. (2011) MicroRNAs in Neural Cell Development and Brain Diseases. Science China (Life Sciences), 54, 1103-1112. <br>https://doi.org/10.1007/s11427-011-4249-8Smirnova, L., Block, K., Sittka, A., et al. (2014) MicroRNA Profiling as Tool for in Vitro Developmental Neurotoxicity Testing: The Case of Sodium Valproate. PLoS ONE, 9, e9892. <br>https://doi.org/10.1371/journal.pone.0098892Choy, E.Y., Siu, K.L., Kok, K.H., Lung, R.W., Tsang, C.M., To, K.F., Kwong, D.L., Tsao, S.W. and Jin, D.Y. (2008) An Epstein-Barr Virus-Encoded microRNA Targets PUMA to Promote Host Cell Survival. Journal of Experimental Medicine, 205, 2551-2560. <br>https://doi.org/10.1084/jem.20072581李春燕, 王跃旗, 寇兰俊, 谢静, 杨婧华, 王妮娜, 潘国忠. microRNA-370对缺氧心肌细胞凋亡的影响及其相关机制的研究[J]. 组织工程与重建外科, 2020, 16(6): 451-455+466.尹波, 李翠翠, 朱应超, 刘公哲. 心脏瓣膜病中线粒体凋亡调控因子与microRNA的相互作用[J]. 基因组学与应用生物学, 2019, 38(9): 4314-4318.Yin, Y., Lv, L. and Wang, W. (2019) Expression of miRNA-214 in the Sera of Elderly Patients with Acute Myocardial Infarction and Its Effect on Cardiomyocyte Apoptosis. Experimental and Therapeutic Medicine, 17, 4657-4662.
<br>https://doi.org/10.3892/etm.2019.7464Tian, J., Pan, W., Xu, X., Tian, X., Zhang, M. and Hu, Q. (2020) NF-kappaB Inhibits the Occurrence of Type 1 Diabetes through microRNA-150-Dependent PUMA Degradation. Life Science, 255, Article ID: 117724.
<br>https://doi.org/10.1016/j.lfs.2020.117724Wang, G.F., Gu, Y., Xu, N., Zhang, M. and Yang, T. (2018) Decreased Expression of miR-150, miR146a and miR424 in Type 1 Diabetic Patients: Association with Ongoing Islet Autoimmunity. Biochemical and Biophysical Research Communications, 498, 382-387. <br>https://doi.org/10.1016/j.bbrc.2017.06.196Cazanave, S.C., Mott, J.L., Elmi, N.A., Bronk, S.F., Masuoka, H.C., Charlton, M.R. and Gores, G.J. (2011) A Role for miR-296 in the Regulation of Lipoapoptosis by Targeting PUMA. Journal of Lipid Research, 52, 1517-1525.
<br>https://doi.org/10.1194/jlr.M014654Yang, Y.L., Kuo, H.C., Wang, F.S., et al. (2019) MicroRNA-29a Disrupts DN-MT3b to Ameliorate Diet-Induced Non-Alcoholic Steatohepatitis in Mice. International Journal of Molecular Sciences, 20, E1499.
<br>https://doi.org/10.3390/ijms20061499Sabirzhanov, B., Makarevich, O., Barrett, J., Jackson, I.L., Faden, A.I. and Stoica, B.A. (2020) Down-Regulation of miR-23a-3p Mediates Irradiation-Induced Neuronal Apoptosis. International Journal of Molecular Sciences, 21, 3695.
<br>https://doi.org/10.3390/ijms21103695Sabirzhanov, B., Faden, A.I., Aubrecht, T., Henry, R., Glaser, E. and Stoica, B.A. (2018) MicroRNA-711-Induced Downregulation of Angiopoietin-1 Mediates Neuronal Cell Death. Journal of Neurotrauma, 35, 2462-2481.
<br>https://doi.org/10.1089/neu.2017.5572Qazi, T.J., Lu, J., Duru, L., Zhao, J. and Qing, H. (2021) Upregulation of mir-132 Induces Dopaminergic Neuronal Death via Activating SIRT1/p53 Pathway. Neuroscience Letters, 740, Article ID: 135465.
<br>https://doi.org/10.1016/j.neulet.2020.135465白莹. miR-143调节血脑屏障完整性及其调控机制[D]: [博士学位论文]. 南京: 东南大学, 2018.Zhang, F., Li, Y., Tang, Z., et al. (2012) Proliferative and Survival Effects of PUMA Promote Angiogenesis. Cell Reports, 22, 1272-1285. <br>https://doi.org/10.1016/j.celrep.2012.09.023Yan, J., Li, L., Khatibi, N.H., et al. (2011) Blood-Brain Barrier Disruption Following Subarchnoid Hemorrhage May Be Faciliated through PUMA Induction of Endothelial Cell Apoptosis from the Endoplasmic Reticulum. Experimental Neurology, 230, 240-247. <br>https://doi.org/10.1016/j.expneurol.2011.04.022Liu, W., Miao, Y., Zhang, L., Xu, X. and Luan, Q. (2020) MiR-211 Protects Cerebral Ischemia/Reperfusion Injury by Inhibiting Cell Apoptosis. Bioengineered, 11, 189-200. <br>https://doi.org/10.1080/21655979.2020.1729322Sabirzhanov, B., Matyas, J., Coll-Miro, M., Yu, L.L., Faden, A.I., Stoica, B.A. and Wu, J. (2019) Inhibition of microRNA-711 Limits Angiopoietin-1 and Akt Changes, Tissue Damage, and Motor Dysfunction after Contusive Spinal Cord Injury in Mice. Cell Death & Disease, 10, Article No. 839. <br>https://doi.org/10.1038/s41419-019-2079-y