高度近视早期容易并发核性白内障并且病情发展较快,引起视力不同程度的下降,影响日常工作和生活,但是此病具体发生机制目前尚不清楚,因此本文在氧化应激损伤;蛋白组学;基因组学;内质网应激;房水中细胞因子、补体因子和蛋白浓度改变;房水和玻璃体中炎性细胞因子表达这几个方面进行阐述,对于了解其发生发展有重要意义。
High myopia is easy to be complicated by nuclear cataract in the early stage and the disease develops rapidly, causing different degrees of vision decline in patients, affecting daily work and life. Therefore, this review focuses on oxidative stress injury; proteomics; genomics; endoplasmic reticulum stress; changes in the concentrations of cytokines, complement factors and proteins in the aqueous humor; and the expression of inflammatory cytokines in aqueous humor and vitreous, which are of great significance for understanding its occurrence and development.
高度近视并发白内障,发病机制, High Myopia with Cataract Pathogenesis摘要
Research Progress on the Related Mechanism of High Myopia with Cataract
Xiao Ren, Lilun Wang*, Denglei Han
Yan’an University Affiliated Hospital, Yan’an Shaanxi
Received: Mar. 8th, 2022; accepted: Mar. 31st, 2022; published: Apr. 12th, 2022
ABSTRACT
High myopia is easy to be complicated by nuclear cataract in the early stage and the disease develops rapidly, causing different degrees of vision decline in patients, affecting daily work and life. Therefore, this review focuses on oxidative stress injury; proteomics; genomics; endoplasmic reticulum stress; changes in the concentrations of cytokines, complement factors and proteins in the aqueous humor; and the expression of inflammatory cytokines in aqueous humor and vitreous, which are of great significance for understanding its occurrence and development.
任 晓,王理论,韩登雷. 高度近视并发白内障相关机制研究进展Research Progress on the Related Mechanism of High Myopia with Cataract[J]. 临床医学进展, 2022, 12(04): 2583-2589. https://doi.org/10.12677/ACM.2022.124372
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