目的:分析孤立性纤维性肿瘤的临床表现、诊断、鉴别诊断和治疗方法,旨在提高妇科医生对该疾病的认识及对危重患者的处理。方法:回顾性分析了郑州大学人民医院妇科收治1例盆腹腔巨大包块伴CA125升高的恶性孤立性纤维性肿瘤患者的病案资料,结合相关文献复习,了解其诊断、鉴别诊断、治疗以及相关预后的研究进展。结果:患者,64岁女性,以“发现腹部占位3年余,腹部不适1周”入院,住院期间病情进一步加重,于我院行手术治疗。术后病理及免疫组化诊断为非典型/恶性孤立性纤维性肿瘤,术后血清CA125恢复正常。随访12个月,患者目前生存良好。结论:孤立性纤维性肿瘤临床表现无特异性,术前诊断较困难,易于其他疾病相混淆。手术是主要的治疗方式,其诊断依靠组织病理及免疫组化,并且需定期随访。
Objective: The clinical characteristics, diagnosis, and treatment of solitary fibrous tumor were analyzed to improve clinicians’ understandings of the disease and the treatment of critically ill patients. Methods: The medical record of a patient with malignant solitary fibrous tumor that manifested as a massive pelvic abdominal mass and elevated CA125 in the Department of Gynecology, People’s Hospital of Zhengzhou University was retrospectively analyzed. Combined with the review of relevant literature, diagnosis, differential diagnosis, treatment, related progress and prognosis were understood. Results: The patient, a 64-year old female, was admitted to the hospital with “abdominal occupancy for more than 3 years and abdominal discomfort for 1 week”. During hospitalization, her condition aggravated, and underwent surgery in our hospital. Atypical/malignant solitary fibrous tumor was diagnosed by postoperative pathology and immunohistochemistry, and serum CA125 returned to normal. After a 12-month follow-up, the patient is currently alive and well. Conclusion: The clinical manifestations of solitary fibrous tumors are not specific, and preoperative diagnosis is difficult, so it is easy to be confused with other diseases. Surgery is the main treatment. The main diagnosis depends on histopathology and immunohistochemistry. Regular follow-up is required.
腹腔肿物,盆腔肿物,孤立性纤维性肿瘤,文献复习, Abdominal Mass Pelvic Mass Solitary Fibrous Tumor Literature Review摘要
Objective: The clinical characteristics, diagnosis, and treatment of solitary fibrous tumor were analyzed to improve clinicians’ understandings of the disease and the treatment of critically ill patients. Methods: The medical record of a patient with malignant solitary fibrous tumor that manifested as a massive pelvic abdominal mass and elevated CA125 in the Department of Gynecology, People’s Hospital of Zhengzhou University was retrospectively analyzed. Combined with the review of relevant literature, diagnosis, differential diagnosis, treatment, related progress and prognosis were understood. Results: The patient, a 64-year old female, was admitted to the hospital with “abdominal occupancy for more than 3 years and abdominal discomfort for 1 week”. During hospitalization, her condition aggravated, and underwent surgery in our hospital. Atypical/malignant solitary fibrous tumor was diagnosed by postoperative pathology and immunohistochemistry, and serum CA125 returned to normal. After a 12-month follow-up, the patient is currently alive and well. Conclusion: The clinical manifestations of solitary fibrous tumors are not specific, and preoperative diagnosis is difficult, so it is easy to be confused with other diseases. Surgery is the main treatment. The main diagnosis depends on histopathology and immunohistochemistry. Regular follow-up is required.
Keywords:Abdominal Mass, Pelvic Mass, Solitary Fibrous Tumor, Literature Review
高 华,苏 杭,黄秀丽,王军陶,赵星浩,杨秋云,刘广芝. 盆腹腔巨大包块伴CA125升高的恶性孤立性纤维性肿瘤1例伴文献复习Malignant Solitary Fibrous Tumor with Huge Pelvic-Abdominal Mass and Elevated CA125: A Case Report and Literature Review[J]. 临床医学进展, 2022, 12(04): 2709-2714. https://doi.org/10.12677/ACM.2022.124389
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