随着经济水平的提高,久坐不动和不健康饮食已成为我国城市居民的主要生活方式,内脏脂肪容易堆积,腹部肥胖已成为大多数人口的特征。内脏脂肪堆积是引起胰岛素抵抗等多种代谢性疾病的重要原因之一,且2型糖尿病与腹型肥胖存在密切相关性,因此评价内脏脂肪堆积成为近年来的研究热点,传统的评价指标如体质量指数、腰围等,均有其相对局限性,而新型的评价指标如内脏脂肪指数和脂质蓄积指数对2型糖尿病的发生有一定预测价值。因此,本篇综述就内脏脂肪指数和脂质蓄积指数与2型糖尿病的关系进行探讨。
With the improvement of economic level, sedentary and unhealthy diets have become the main lifestyle of urban residents in China, visceral fat is easy to accumulate, and abdominal obesity has become a feature of the majority of the population. Visceral fat accumulation is one of the important causes of metabolic diseases such as insulin resistance, and type 2 diabetes mellitus is closely correlated with abdominal obesity. Therefore, evaluation of visceral fat accumulation has become a research hotspot in recent years, and traditional evaluation indexes such as body mass index and waist circumference have their relative limitations. New indexes such as visceral adipose index and lipid accumulation product have certain predictive value for the occurrence of type 2 diabetes. Therefore, this review discussed the relationship between visceral adipose index and lipid accumulation product and type 2 diabetes mellitus.
2型糖尿病,内脏脂肪指数,脂质蓄积指数, Type 2 Diabetes Mellitus Visceral Adipose Index Lipid Accumulation Product摘要
With the improvement of economic level, sedentary and unhealthy diets have become the main lifestyle of urban residents in China, visceral fat is easy to accumulate, and abdominal obesity has become a feature of the majority of the population. Visceral fat accumulation is one of the important causes of metabolic diseases such as insulin resistance, and type 2 diabetes mellitus is closely correlated with abdominal obesity. Therefore, evaluation of visceral fat accumulation has become a research hotspot in recent years, and traditional evaluation indexes such as body mass index and waist circumference have their relative limitations. New indexes such as visceral adipose index and lipid accumulation product have certain predictive value for the occurrence of type 2 diabetes. Therefore, this review discussed the relationship between visceral adipose index and lipid accumulation product and type 2 diabetes mellitus.
陈停停,赵成玉. 内脏脂肪指数、脂质蓄积指数与2型糖尿病的关系Relationship between Visceral Adipose Index, Lipid Accumulation Product and Type 2 Diabetes Mellitus[J]. 临床医学进展, 2022, 12(04): 3350-3355. https://doi.org/10.12677/ACM.2022.124484
参考文献ReferencesKing, H., Aubert, R.E. and Herman, W.H. (1998) Global Burden of Diabetes, 1995-2025: Prevalence, Numerical Esti-mates, and Projections. Diabetes Care, 21, 1414-1431. <br>https://doi.org/10.2337/diacare.21.9.1414Caprio, S., Perry, R. and Kursawe, R. (2017) Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation. Gastroenterology, 152, 1638-1646. <br>https://doi.org/10.1053/j.gastro.2016.12.051Hwang, Y.C., Hayashi, T., Fujimoto, W.Y., et al. (2015) Vis-ceral Abdominal Fat Accumulation Predicts the Conversion of Metabolically Healthy Obese Subjects to an Unhealthy Phenotype. International Journal of Obesity, 39, 1365-1370. <br>https://doi.org/10.1038/ijo.2015.75Yun, C.H., Bezerra, H.G., Wu, T.H., et al. (2013) The Normal Limits, Subclinical Significance, Related Metabolic Derangements and Distinct Biological Effects of Body Site-Specific Adiposity in Relatively Healthy Population. PLoS ONE, 8, e61997. <br>https://doi.org/10.1371/journal.pone.0061997Casanueva, F.F., et al. (2010) Relationship of Abdominal Obesity with Cardiovascular Disease, Diabetes and Hyperlipidaemia in Spain. Clinical Endocrinology, 73, 35-40.Kim, J.A., Hwang, S.Y., Chung, H.S., et al. (2019) Proportion and Characteristics of the Subjects with Low Muscle Mass and Abdominal Obesity among the Newly Diagnosed and Drug-Naïve Type 2 Diabetes Mellitus Pa-tients. Diabetes & Metabolism Journal, 43, 105-113. <br>https://doi.org/10.4093/dmj.2018.0036Wakabayashi, I. and Daimon, T. (2014) A Strong Association between Lipid Accumulation Product and Diabetes Mellitus in Japanese Women and Men. Journal of Atherosclerosis and Thrombosis, 21, 282-288.Xing, Z.H., Pei, J.Y., Huang, J.B., et al. (2018) Relationship of Obesity to Adverse Events among Patients with Mean 10-Year History of Type 2 Diabetes Mellitus: Results of the ACCORD Study. Journal of the American Heart Association, 7, e010512. <br>https://doi.org/10.1161/JAHA.118.010512Albrecht, S.S., Mayer-Davis, E. and Popkin, B.M. (2017) Secular and Race/Ethnic Trends in Glycemic Outcomes by BMI in US Adults: The Role of Waist Circumference. Diabe-tes/Metabolism Research and Reviews, 33, e2889.
<br>https://doi.org/10.1002/dmrr.2889Hou, X.H., et al. (2019) Stronger Associations of waist Circumference and Waist-to-Height Ratio with Diabetes than BMI in Chinese Adults. Diabetes Research and Clinical Practice, 147, 9-18.
<br>https://doi.org/10.1016/j.diabres.2018.07.029Pajunen, P., Rissanen, H., Laaksonen, M.A., et al. (2013) Sagittal Abdominal Diameter as a New Predictor for Incident Diabetes. Diabetes Care, 36, 283-288. <br>https://doi.org/10.2337/dc11-2451Schlett, C.L. and Hoffmann, U. (2011) Identifikation und Quantifizierung von Fettkompartimenten mit CT und MRT und deren Stellenwert [Identification and Quantification of Fat Compartments with CT and MRI and Their Importance]. Der Radiologe, 51, Article No. 372. <br>https://doi.org/10.1007/s00117-010-2088-4Amato, M.C., Giordano, C., Galia, M., et al. (2010) Visceral Adiposity Index: A Reliable Indicator of Visceral Fat Function Associated with Cardiometabolic Risk. Diabetes Care, 33, 920-922. <br>https://doi.org/10.2337/dc09-1825Kahn, H.S. (2005) The “Lipid Accumulation Product” Performs Better than the Body Mass Index for Recognizing Cardiovascular Risk: A Population-Based Comparison. BMC Cardiovascular Disorders, 5, Article No. 26.
<br>https://doi.org/10.1186/1471-2261-5-26Amato, M.C., Giordano, C., Pitrone, M. and Galluzzo, A. (2011) Cut-Off Points of the Visceral Adiposity Index (VAI) Identifying a Visceral Adipose Dysfunction Associated with Cardiometabolic Risk in a Caucasian Sicilian Population. Lipids in Health and Disease, 10, Article No. 183. <br>https://doi.org/10.1186/1476-511X-10-183申元媛, 陈纪春, 李刚, 曹杰, 李建新, 黄建凤, 顾东风. 北京市常住居民脂质蓄积指数与高血压、糖尿病的关系[J]. 中华预防医学杂志, 2017, 51(5): 415-420.Oh, J.Y., Sung, Y.A. and Lee, H.J. (2013) The Visceral Adiposity Index as a Predictor of Insulin Resistance in Young Women with Polycystic Ovary Syndrome. Obesity, 21, 1690-1694. <br>https://doi.org/10.1002/oby.20096刘晨, 张黎军. 新型体脂指数脂质蓄积指数和内脏脂肪指数的相关研究进展[J]. 中国糖尿病杂志, 2016, 24(11): 1032-1035.Roriz, A.K.C., Passos, L.C.S., de Oliveira, C.C., et al. (2014) Evaluation of the Accuracy of An-thropometric Clinical Indicators of Visceral Fat in Adults and Elderly. PLoS ONE, 9, e103499. <br>https://doi.org/10.1371/journal.pone.0103499Wang, Y., He, S., He, J., et al. (2015) Predictive Value of Visceral Adiposity Index for Type 2 Diabetes Mellitus: A 15-Year Prospective Cohort Study. Herz, 40, 277-281. <br>https://doi.org/10.1007/s00059-014-4175-1Al-Daghri, N.M., Al-Attas, O.S., Alokail, M.S., et al. (2013) Visceral Adiposity Index Is Highly Associated with Adiponectin Values and Glycaemic Disturbances. European Journal of Clinical Investigation, 43, 183-189.
<br>https://doi.org/10.1111/eci.12030Bozorgmanesh, M., Hadaegh, F. and Azizi, F. (2011) Predictive Perfor-mance of the Visceral Adiposity Index for a Visceral Adiposity-Related Risk: Type 2 Diabetes. Lipids in Health and Disease, 10, Article No. 88.
<br>https://doi.org/10.1186/1476-511X-10-88Amato, M.C., Pizzolanti, G., Torregrossa, V., et al. (2014) Visceral Adiposity Index (VAI) Is Predictive of an Altered Adipokine Profile in Patients with Type 2 Diabetes. PLoS ONE, 9, e91969.
<br>https://doi.org/10.1371/journal.pone.0091969Zhang, M., Zhang, L., Zhu, Y., et al. (2016) 4-Year Trajectory of Visceral Adiposity Index in the Development of Type 2 Diabetes: A Prospective Cohort Study. Annals of Nutrition & Metabolism, 69, 142-149.
<br>https://doi.org/10.1159/000450657Štěpánek, L., Horáková, D., Cibičková, L., et al. (2019) Can Visceral Adiposity Index Serve as a Simple Tool for Identifying Individuals with Insulin Resistance in Daily Clinical Practice? Medicina, 55, Article No. 545.
<br>https://doi.org/10.3390/medicina55090545Nusrianto, R., Tahapary, D.L. and Soewondo, P. (2019) Visceral Adiposity Index as a Predictor for Type 2 Diabetes Mellitus in Asian Population: A Systematic Review. Diabetes & Metabolic Syndrome, 13, 1231-1235.
<br>https://doi.org/10.1016/j.dsx.2019.01.056Carr, M.C. and Brunzell, J.D. (2004) Abdominal Obesity and Dyslipidemia in the Metabolic Syndrome: Importance of Type 2 Diabetes and Familial Combined Hyperlipidemia in Coronary Artery Disease Risk. The Journal of Clinical Endocrinology and Metabolism, 89, 2601-2607. <br>https://doi.org/10.1210/jc.2004-0432Navarro, G., Allard, C., Xu, W. and Mauvais-Jarvis, F. (2015) The Role of Androgens in Metabolism, Obesity, and Diabetes in Males and Females. Obesity, 23, 713-719. <br>https://doi.org/10.1002/oby.21033Kahn, H.S. (2006) The Lipid Accumulation Product Is Better than BMI for Identifying Diabetes: A Population-Based Comparison. Diabetes Care, 29, 151-153. <br>https://doi.org/10.2337/diacare.29.01.06.dc05-1805Bozorgmanesh, M., Hadaegh, F. and Azizi, F. (2010) Diabetes Prediction, Lipid Accumulation Product, and Adiposity Measures; 6-Year Follow-Up: Tehran Lipid and Glucose Study. Lipids in Health and Disease, 9, Article No. 45.
<br>https://doi.org/10.1186/1476-511X-9-45Mirmiran, P., Bahadoran, Z. and Azizi, F. (2014) Lipid Accumula-tion Product Is Associated with Insulin Resistance, Lipid Peroxidation, and Systemic Inflammation in Type 2 Diabetic Patients. Endocrinology and Metabolism, 29, 443-449. <br>https://doi.org/10.3803/EnM.2014.29.4.443Nusrianto, R., Ayundini, G., Kristanti, M., et al. (2019) Visceral Adiposity Index and Lipid Accumulation Product as a Predictor of Type 2 Diabetes Mellitus: The Bogor Cohort Study of Non-Communicable Diseases Risk Factors. Diabetes Research and Clinical Practice, 155, Article ID: 107798. <br>https://doi.org/10.1016/j.diabres.2019.107798