芬芥素是一类具备优异抗丝状真菌活性的环状脂肽,有望在植物保护、医疗健康、食品防腐等领域发挥重要作用。芬芥素的制备主要依赖于芽孢杆菌的生物合成。介绍了近年来在芬芥素合成途径、芬芥素合成关键基因挖掘、芬芥素合成工程菌的开发等方面取得的新进展,以期为芬芥素的生物合成、生物活性与合成生物学的深入研究提供参考。
Fengycin is a kind of cyclic lipopeptides with strong antifungal activity against filamentous fungi, which is expected to play an important role in plant protection, health care, food antisepsis and other fields. The preparation of fengycin mainly depends on the biosynthesis of bacillus species. The recent progress in the synthesis pathway, key gene discovery, and the development of engineering bacteria for fengycin synthesis are reviewed, in order to provide reference for the further study of fengycin biosynthesis, biological activity and synthetic biology.
1Institute of Microbiology Heilongjiang Academy of Sciences, Harbin Heilongjiang
2Department of Medicine, Wuhai Vocational and Technical College, Wuhai Inner Mongolia
Received: Apr. 25th, 2022; accepted: May 10th, 2022; published: May 19th, 2022
ABSTRACT
Fengycin is a kind of cyclic lipopeptides with strong antifungal activity against filamentous fungi, which is expected to play an important role in plant protection, health care, food antisepsis and other fields. The preparation of fengycin mainly depends on the biosynthesis of bacillus species. The recent progress in the synthesis pathway, key gene discovery, and the development of engineering bacteria for fengycin synthesis are reviewed, in order to provide reference for the further study of fengycin biosynthesis, biological activity and synthetic biology.
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