幽门螺杆菌(Helicobacter pylori, Hp)是一种革兰阴氏菌,感染世界近半人数,约85%左右的感染者并无特殊临床表现,但可导致胃炎、消化性或十二指肠溃疡、胃腺癌和黏膜相关组织淋巴瘤等严重不良远期预后,高海拔地区具有低氧、寒冷的环境特征,且医疗、卫生等条件差,较低海拔地区幽门螺杆菌感染率更高,故对于幽门螺杆菌的精准检测对于治疗防治意义深远。目前Hp提供了多种常规检测方法,包括粪便抗原检测、快速尿素酶试验等,及近年来国内外研究的热点聚合酶链式反应(PCR)检测方法。本文通过对高海拔地区幽门螺杆菌感染研究现状加以综述,探讨一检测效能更高的方法,以期精准的检测高海拔地区居民Hp感染者并能达到高清除率来提高高海拔地区人民生活质量。
Helicobacter pylori is a gram-negative bacterium, which infects nearly half of the world. About 85% of the infected people have no special clinical manifestations, but it can lead to serious adverse long-term prognosis such as gastritis, peptic or duodenal ulcer, gastric adenocarcinoma and mucosa associated tissue lymphoma. High altitude areas have the characteristics of hypoxia and cold envi-ronment, and the medical and health conditions are poor. The infection rate of Helicobacter pylori is higher in lower altitude areas. Therefore, the accurate detection of Helicobacter pylori is of far-reaching significance for treatment and prevention. At present, HP provides a variety of conven-tional detection methods, including fecal antigen detection, rapid urease test, and polymerase chain reaction (PCR) detection method, which is a research hotspot at home and abroad in recent years. This paper summarizes the research status of Helicobacter pylori infection in high- altitude areas, and discusses a method with higher detection efficiency, in order to accurately detect HP infected residents in high-altitude areas and achieve high-definition elimination rate to improve the quality of life of people in high-altitude areas.
幽门螺杆菌,高海拔地区,检测,PCR,研究现状, Helicobacter pylori High Altitude Areas Testing PCR Research Status摘要
Research Status of Helicobacter pylori Infection in High Altitude Areas
Mingyuan Xin
School of Clinical Medicine, Qinghai University, Xining Qinghai
Received: Apr. 25th, 2022; accepted: May 19th, 2022; published: May 27th, 2022
ABSTRACT
Helicobacter pylori is a gram-negative bacterium, which infects nearly half of the world. About 85% of the infected people have no special clinical manifestations, but it can lead to serious adverse long-term prognosis such as gastritis, peptic or duodenal ulcer, gastric adenocarcinoma and mucosa associated tissue lymphoma. High altitude areas have the characteristics of hypoxia and cold environment, and the medical and health conditions are poor. The infection rate of Helicobacter pylori is higher in lower altitude areas. Therefore, the accurate detection of Helicobacter pylori is of far-reaching significance for treatment and prevention. At present, HP provides a variety of conventional detection methods, including fecal antigen detection, rapid urease test, and polymerase chain reaction (PCR) detection method, which is a research hotspot at home and abroad in recent years. This paper summarizes the research status of Helicobacter pylori infection in high-altitude areas, and discusses a method with higher detection efficiency, in order to accurately detect HP infected residents in high-altitude areas and achieve high-definition elimination rate to improve the quality of life of people in high-altitude areas.
Keywords:Helicobacter pylori, High Altitude Areas, Testing, PCR, Research Status
辛明远. 高海拔地区幽门螺杆菌感染研究现状Research Status of Helicobacter pylori Infection in High Altitude Areas[J]. 临床医学进展, 2022, 12(05): 4571-4577. https://doi.org/10.12677/ACM.2022.125660
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