脑卒中是常见的急危重症,患病率高、病死率高,是我国居民第一死亡原因。脑卒中后谵妄(post-stroke delirium, PSD)是卒中急性期常见的并发症,严重影响患者的康复与生存质量。早期识别并干预能有效降低PSD的死亡率。本文主要归纳了中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio, NLR)及C反应蛋白(C-reactive protein, CRP)与PSD的关系,对PSD的发病率及影响因素、发病机制、诊断及评估工具、治疗等方面的研究进展进行综述。最后指出NLR及CRP升高可以作为预测急性脑卒中后谵妄的潜在标志物。
Stroke is a common acute and critical illness with a high prevalence and mortality rate, and is the leading cause of death in China. Post-stroke delirium (PSD) is a common complication in the acute phase of stroke, and has a serious impact on patients’ recovery and quality of life. Early recognition and intervention can effectively reduce mortality from PSD. This article reviews the relationship between neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) and PSD, as well as the incidence and factors affecting PSD, pathogenesis, diagnostic and assessment tools, and treatment. Finally, it is suggested that elevated NLR and CRP can be used as potential markers to predict de-lirium after acute stroke.
卒中后谵妄,中性粒细胞与淋巴细胞比值,C反应蛋白, Post-Stroke Delirium Neutrophil-to-Lymphocyte Ratio C-Reactive Protein摘要
2Affiliated Hospital of Qinghai University, Xining Qinghai
Received: Apr. 27th, 2022; accepted: May 21st, 2022; published: May 31st, 2022
ABSTRACT
Stroke is a common acute and critical illness with a high prevalence and mortality rate, and is the leading cause of death in China. Post-stroke delirium (PSD) is a common complication in the acute phase of stroke, and has a serious impact on patients’ recovery and quality of life. Early recognition and intervention can effectively reduce mortality from PSD. This article reviews the relationship between neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) and PSD, as well as the incidence and factors affecting PSD, pathogenesis, diagnostic and assessment tools, and treatment. Finally, it is suggested that elevated NLR and CRP can be used as potential markers to predict delirium after acute stroke.
Keywords:Post-Stroke Delirium, Neutrophil-to-Lymphocyte Ratio, C-Reactive Protein
熊子超,鲍海咏. NLR联合CRP对脑卒中后谵妄的预测价值Predictive Value of NLR Combined with CRP in Post-Stroke Delirium[J]. 临床医学进展, 2022, 12(05): 4817-4822. https://doi.org/10.12677/ACM.2022.125699
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