膝关节骨性关节炎(knee osteoarthritis, KOA)是中老年人常见的致残疾病之一,严重地影响了中老年人的日常生活。随着人口老龄化的增长,患有膝关节骨性关节炎的病人逐年增加,然而膝关节骨性关节的发病机制仍不明确,膝关节骨性关节炎多表现为关节疼痛、肿胀、僵硬、活动时可闻及摩擦音及关节畸形等;病理改变多表现为软骨下骨硬化、骨赘形成和关节间隙变窄等。目前,膝关节骨性关节炎多被认为是整个关节器官的病变,有研究表明除滑膜和软骨外,髌下脂肪垫也可能参与了膝关节骨性关节炎的发生发展过程,然而髌下脂肪在膝关节的具体作用在国内外尚无明确的定论。本文就髌下脂肪垫在膝关节骨性关节炎的作用作一综述,以便对膝关节骨性关节炎的发病过程有更清楚的了解,为临床治疗膝关节骨性关节炎提供新的思路。
Knee osteoarthritis (KOA) is one of the common disabling diseases in the middle-aged and elderly, which seriously affects the daily life of the middle-aged and elderly. With the aging of the population, the number of patients with knee osteoarthritis is increasing year by year. However, the pathogen-esis of knee osteoarthritis is still unclear. Knee osteoarthritis is mostly manifested in joint pain, swelling, stiffness, audible friction sound and joint deformity; pathological changes were mainly subchondral bone sclerosis, osteophyte formation and narrowing of joint space. At present, knee osteoarthritis is mostly considered to be the disease of the whole joint organ. Some studies have shown that in addition to synovium and cartilage, infrapatellar fat pad may also be involved in the occurrence and development of knee osteoarthritis. However, the specific role of infrapatellar fat in knee joint has not been clearly determined at home and abroad. This paper reviews the role of in-frapatellar fat pad in knee osteoarthritis, so as to have a clearer understanding of the pathogenesis of knee osteoarthritis and provide new ideas for clinical treatment of knee osteoarthritis.
膝关节骨性关节炎,髌下脂肪垫,发病机制, Knee Osteoarthritis Infrapatellar Fat Pad Pathogenesis摘要
The Role of Infrapatellar Fat Pad in Knee Osteoarthritis
Yulong Zhu, Guoqiu Zhang*
Qinghai University, Xining Qinghai
Received: May 10th, 2022; accepted: May 27th, 2022; published: Jun. 13th, 2022
ABSTRACT
Knee osteoarthritis (KOA) is one of the common disabling diseases in the middle-aged and elderly, which seriously affects the daily life of the middle-aged and elderly. With the aging of the population, the number of patients with knee osteoarthritis is increasing year by year. However, the pathogenesis of knee osteoarthritis is still unclear. Knee osteoarthritis is mostly manifested in joint pain, swelling, stiffness, audible friction sound and joint deformity; pathological changes were mainly subchondral bone sclerosis, osteophyte formation and narrowing of joint space. At present, knee osteoarthritis is mostly considered to be the disease of the whole joint organ. Some studies have shown that in addition to synovium and cartilage, infrapatellar fat pad may also be involved in the occurrence and development of knee osteoarthritis. However, the specific role of infrapatellar fat in knee joint has not been clearly determined at home and abroad. This paper reviews the role of infrapatellar fat pad in knee osteoarthritis, so as to have a clearer understanding of the pathogenesis of knee osteoarthritis and provide new ideas for clinical treatment of knee osteoarthritis.
朱玉龙,张国秋. 髌下脂肪垫在膝关节骨性关节炎的作用The Role of Infrapatellar Fat Pad in Knee Osteoarthritis[J]. 临床医学进展, 2022, 12(06): 5160-5165. https://doi.org/10.12677/ACM.2022.126748
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