慢性阻塞性肺疾病(COPD)是一种全球高发的肺部疾病。目前普遍认为慢性气道炎症和肺气肿是COPD主要疾病表现,肺组织损伤与修复失衡是COPD疾病进展的主要原因。初期炎症损伤中许多炎症因子参与COPD的病理生理过程,但他们不具有特异性。近年来发现MIF、MMP-9与COPD疾病发展最为密切,本文就炎症因子MIF、MMP-9与COPD发展作一综述。
Chronic obstructive pulmonary disease (COPD) is a global incidence of lung disease. It is currently widely believed that chronic airway inflammation and emphysema are the major disease manifes-tations of COPD, and the imbalance between lung tissue injury and repair is the main cause of dis-ease progression in COPD. Many inflammatory factors in the initial inflammatory injury are involved in the pathophysiological process of COPD, but they are not specific. In recent years, MIF and MMP-9 were found to develop most closely with COPD diseases. Here, we review the development of in-flammatory cytokines MIF, MMP-9 and COPD.
Chronic obstructive pulmonary disease (COPD) is a global incidence of lung disease. It is currently widely believed that chronic airway inflammation and emphysema are the major disease manifestations of COPD, and the imbalance between lung tissue injury and repair is the main cause of disease progression in COPD. Many inflammatory factors in the initial inflammatory injury are involved in the pathophysiological process of COPD, but they are not specific. In recent years, MIF and MMP-9 were found to develop most closely with COPD diseases. Here, we review the development of inflammatory cytokines MIF, MMP-9 and COPD.
张海刚,久 太. MIF、MMP-9与慢性阻塞性肺疾病的研究进展Research Progress of MIF, MMP-9, and Chronic Obstructive Pulmonary Disease[J]. 临床医学进展, 2022, 12(06): 5583-5590. https://doi.org/10.12677/ACM.2022.126807
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