在全球范围内,儿童食物过敏(FA)的患病率高达8%,成为影响儿童健康的主要因素之一,并引起了广泛的关注。目前对FA的标准治疗方法是严格回避过敏食物,但存在患者依从性不佳、过敏反应发生、负面心理问题等诸多问题。而近年来,对FA的过敏原免疫疗法的研究是一个非常热门的研究领域,且被认为是FA最有希望的治疗方法。而口服免疫疗法(OIT)是研究最多的方法,但是它仍存在很多问题需要解决。本文就OIT后的疗效、安全性及对生活质量的影响方面的研究进展进行综述。
The prevalence of food allergy (FA) in children is as high as 8% worldwide, which has become one of the major factors affecting children’s health and has attracted widespread attention. At present, the standard treatment for FA is to strictly avoid allergic foods, but there are many problems such as poor patient dependence, occurrence of allergic reactions and negative psychological problems. In recent years, allergen immunotherapy (AIT) for FA is a very hot research area, and is considered to be the most promising treatment for FA. Oral immunotherapy (OIT) is the most studied method, but it still has many problems to solve. This article reviews the research progress of efficacy, safety and quality of life after OIT.
儿童,食物过敏,口服免疫疗法,嗜酸粒细胞性食管炎,生活质量, Children Food Allergy (FA) Oral Immunotherapy (OIT) Eosinophilic Esophagitis (EOE) Quality of Life摘要
The prevalence of food allergy (FA) in children is as high as 8% worldwide, which has become one of the major factors affecting children’s health and has attracted widespread attention. At present, the standard treatment for FA is to strictly avoid allergic foods, but there are many problems such as poor patient dependence, occurrence of allergic reactions and negative psychological problems. In recent years, allergen immunotherapy (AIT) for FA is a very hot research area, and is considered to be the most promising treatment for FA. Oral immunotherapy (OIT) is the most studied method, but it still has many problems to solve. This article reviews the research progress of efficacy, safety and quality of life after OIT.
Keywords:Children, Food Allergy (FA), Oral Immunotherapy (OIT), Eosinophilic Esophagitis (EOE), Quality of Life
因此,免疫治疗的出现给患者及其家庭带来很大的希望。目前最有前途的治疗策略是OIT和生物制剂(如奥玛珠单抗)。近年来,在对鸡蛋、牛奶和花生过敏的各种OIT研究中,已经显示出强烈的脱敏水平。欧洲过敏和临床免疫学会(European Society of Allergy and Clinical Immunology, EAACI)指出,OIT是迄今为止唯一可能治愈FA的治疗方法,能够调节免疫系统和改变疾病的自然病程 [2]。而在2020年1月,美国食品和药物管理局(US Food and Drug Administration, FDA)批准的花生OIT标准化制剂(AR101)成为首个用于FA治疗的药物 [3]。尽管如此,OIT的长期疗效、安全性和生活质量的影响方面仍有待进一步研究。本文就OIT以上几方面的研究进展进行综述。
白金梅,卢 蓉,高春燕. 儿童食物过敏口服免疫疗法的研究进展Progress in Oral Immunotherapy of Food Allergy in Children[J]. 临床医学进展, 2022, 12(10): 8871-8876. https://doi.org/10.12677/ACM.2022.12101280
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