骨缺损是骨科临床常见热点,而传统的骨缺损治疗方法各有优缺点,大都不能达到预期希望,故骨组织工程技术已经成为目前发展热点。而目前脂肪干细胞已成为骨组织工程技术的首选种子细胞。在利用脂肪干细胞修复骨缺损的过程中,有三个重要因素:能够进行成骨分化的细胞、生长因子和支架材料,前两个因素目前已有大量研究,故目前最需要找的就是合适的细胞支架,目前已有很多相关实验,现将一些利用不同支架复合脂肪干细胞修复兔骨缺损的实验进行综述。
Bone defect is a common clinical hot spot in orthopaedics, and traditional bone defect treatment methods have their own advantages and disadvantages, and most of them fail to meet expectations. Therefore, bone tissue engineering technology has become a current development hotspot. At pre-sent, adipose-derived stem cells have become the preferred seed cells for bone tissue engineering technology. In the process of using adipose-derived stem cells to repair bone defects, there are three important factors: cells capable of osteogenic differentiation, growth factors and scaffold ma-terials. The first two factors have been extensively studied, so the most important thing to find is suitable cells. Scaffolds, there are many related experiments, some experiments using different scaffolds combined with adipose stem cells to repair bone defects in rabbits are reviewed.
兔,骨缺损,脂肪干细胞,细胞支架, Rabbit Bone Defect Adipose Stem Cells Cell Scaffold摘要
Bone defect is a common clinical hot spot in orthopaedics, and traditional bone defect treatment methods have their own advantages and disadvantages, and most of them fail to meet expectations. Therefore, bone tissue engineering technology has become a current development hotspot. At present, adipose-derived stem cells have become the preferred seed cells for bone tissue engineering technology. In the process of using adipose-derived stem cells to repair bone defects, there are three important factors: cells capable of osteogenic differentiation, growth factors and scaffold materials. The first two factors have been extensively studied, so the most important thing to find is suitable cells. Scaffolds, there are many related experiments, some experiments using different scaffolds combined with adipose stem cells to repair bone defects in rabbits are reviewed.
Keywords:Rabbit, Bone Defect, Adipose Stem Cells, Cell Scaffold
熊永斌,李春亮,刘俊豪,何永好,冷梓豪. 脂肪干细胞联合不同支架修复骨缺损的实验进展Experimental Progress of Adipose-Derived Stem Cells Combined with Different Scaffolds to Repair Bone Defects[J]. 临床医学进展, 2022, 12(10): 8951-8956. https://doi.org/10.12677/ACM.2022.12101294
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