治疗相关性髓系肿瘤(t-MNs)是实体肿瘤患者化疗和(或)放疗后继发的急性髓性白血病(AML)。文献报道的t-MNs多以一种实体肿瘤继发为主,而相继患两种实体瘤治疗后的t-MNs患者较为罕见。现报道1例经我院诊治的治疗相关性髓系肿瘤患者的资料。
Therapy-related myeloid neoplasms (t-MNs) are acute myeloid leukemia (AML) secondary to chem-otherapy and/or radiotherapy in patients with solid tumors. t-MNs reported in the literature are mainly secondary to one type of solid tumor, while t-MNs patients with two types of solid tumor af-ter treatment are relatively rare. A case of therapy-related myeloid neoplasms diagnosed and treated in our hospital was reported.
Therapy-related myeloid neoplasms (t-MNs) are acute myeloid leukemia (AML) secondary to chemotherapy and/or radiotherapy in patients with solid tumors. t-MNs reported in the literature are mainly secondary to one type of solid tumor, while t-MNs patients with two types of solid tumor after treatment are relatively rare. A case of therapy-related myeloid neoplasms diagnosed and treated in our hospital was reported.
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1. 引言
治疗相关性髓系肿瘤(t-MNs)是实体肿瘤患者化疗和(或)放疗后继发的急性髓性白血病(AML)。t-MNs在人群中的发病率约为0.62/10万 [1]。Claerhout H [2] 等人收集了1995年1月至2017年1月鲁汶大学医院的t-MNs病例并进行回顾性审查、收集和分析,发现t-MNs最常见的原发肿瘤为乳腺癌,其次是低度B细胞非霍奇金淋巴瘤(B-NHL),高度B-NHL和霍奇金淋巴瘤(HL)。随着各类实体肿瘤治疗方案不断更新,患者生存期延长的同时t-MNs的发病率也逐年增加。现将我院收治的1例胃癌继发肺癌,化疗后出现急性髓系白血病患者的诊疗情况报道如下。
贺瑾瑶,魏绪仓. 化疗药物治疗双实体肿瘤后继发急性髓系白血病1例并文献复习Acute Myeloid Leukemia Secondary to Chemotherapy Drug for Double Solid Tumors: A Case Report and Literature Review[J]. 临床医学进展, 2022, 12(10): 9151-9154. https://doi.org/10.12677/ACM.2022.12101323
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