慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease)是导致死亡的第三大原因,也是世界范围内的一个主要健康问题,慢性阻塞性肺病并发急性加重,与医用支出和高发病率相关。COPD急性加重型患者存在影响血清电解质失衡的因素,如缺氧、呼吸性酸中毒、代谢异常(如血清电解质失衡、尿毒症、肝功能异常)。本文旨在对入院后电解质水平对慢阻肺患者的病情相关性作一综述。
Chronic obstructive pulmonary disease is the third leading cause of death and a major health prob-lem worldwide. Acute exacerbation of chronic obstructive pulmonary disease is associated with medical expenditures and high morbidity. There are factors affecting serum electrolyte imbalance in patients with acute and severe COPD, such as hypoxia, respiratory acidosis, and metabolic ab-normalities (such as serum electrolyte imbalance, uremia, and abnormal liver function). The pur-pose of this article is to review the correlation of electrolyte levels in patients with COPD after ad-mission.
Chronic obstructive pulmonary disease is the third leading cause of death and a major health problem worldwide. Acute exacerbation of chronic obstructive pulmonary disease is associated with medical expenditures and high morbidity. There are factors affecting serum electrolyte imbalance in patients with acute and severe COPD, such as hypoxia, respiratory acidosis, and metabolic abnormalities (such as serum electrolyte imbalance, uremia, and abnormal liver function). The purpose of this article is to review the correlation of electrolyte levels in patients with COPD after admission.
张苗苗,孙伟民. 血清电解质水平对COPD价值研究The Research Value of Serum Electrolyte Level in Chronic Obstructive Pulmonary Dis-ease[J]. 临床医学进展, 2022, 12(10): 9309-9313. https://doi.org/10.12677/ACM.2022.12101347
参考文献ReferencesGOLD (2018) Global Initiative for Chronic Obstructive Lung Disease. 1-123.Vogelmeier, C.F., Criner, G.J., Martinez, F.J., et al. (2017) Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary. American Journal of Respiratory and Critical Care Medicine, 195, 557-582. <br>https://doi.org/10.1164/rccm.201701-0218PPWedzicha, J.A. and Seemungal, T.A. (2007) COPD Exacerbations: Defining Their Cause and Prevention. The Lancet, 370, 786-796. <br>https://doi.org/10.1016/S0140-6736(07)61382-8Goli, G., Mukka, R. and Sairi, S. (2016) Study of Serum Electrolytes in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients. International Journal of Re-search in Medical Sciences, 4, 3324-3327.
<br>https://doi.org/10.1007/s00408-009-9222-yAgusti, A. and Faner, R. (2019) Lung Function Trajectories in Health and Disease. The Lancet Respiratory Medicine, 7, 358-364. <br>https://doi.org/10.1016/S2213-2600(18)30529-0van der Molen, T., Miravitlles, M. and Kocks, J.W. (2013) COPD Management: Role of Symptom Assessment in Routine Clinical Practice. International Journal of Chronic Ob-structive Pulmonary Disease, 8, 461-471.
<br>https://doi.org/10.2147/COPD.S49392Lange, P., Celli, B., Agusti, A., et al. (2015) VestboLung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease. The New England Journal of Medicine, 373, 111-122. <br>https://doi.org/10.1056/NEJMoa1411532Celli, B.R., Thomas, N.E. anderson, J.A., et al. (2008) Effect of Pharmacotherapy on Rate of Decline of Lung Function in Chronic Obstructive Pulmonary Disease: Results from the TORCH Study. American Journal of Respiratory and Critical Care Medicine, 178, 332-333. <br>https://doi.org/10.1164/rccm.200712-1869OCHoward, P. (1970) A Long-Term Follow-Up of Respiratory Symptoms and Ventilatory Function in a Group of Working Men. British Journal of Industrial Medicine, 27, 326-333. <br>https://doi.org/10.1136/oem.27.4.326Silverman, E.K. (2007) Exacerbations in Chronic Obstructive Pulmonary Disease: Do They Contribute to Disease Progression? Proceedings of the American Thoracic Society, 4, 586-590. <br>https://doi.org/10.1513/pats.200706-068THDransfield, M.T., Kunisaki, K.M., Strand, M.J., et al. (2016) Acute Exacerbations and Lung Function Loss in Smokers with and without COPD. American Journal of Respiratory and Critical Care Medicine, 195, 324-330.
<br>https://doi.org/10.1164/rccm.201605-1014OCDonaldson, G.C., Law, M., Kowlessar, B., et al. (2015) Impact of Prolonged Exacerbation Recovery in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, 192, 943-950.
<br>https://doi.org/10.1164/rccm.201412-2269OCBurg, M.B. and Ferraris, J.D. (2008) Intracellular Organic Osmolytes: Function and Regulation. Journal of Biological Chemistry, 283, 7309-7313. <br>https://doi.org/10.1074/jbc.R700042200Palmer, L.G. and Schnermann, J. (2015) Integrated Control of Na Transport along the Nephron. Clinical Journal of the American Society of Nephrology, 10, 676-687. <br>https://doi.org/10.2215/CJN.12391213Sterns, R.H., Nigwekar, S.U. and Hix, J.K. (2009) The Treatment of Hyponatremia. Seminars in Nephrology, 29, 282-299. <br>https://doi.org/10.1016/j.semnephrol.2009.03.002Sterns, R.H., Riggs, J.E. and Schochet Jr., S.S. (1986) Osmotic Demyelination Syndrome Following Correction of Hyponatremia. The New England Journal of Medicine, 314, 1535-1542.
<br>https://doi.org/10.1056/NEJM198606123142402Gankam-Kengne, F., Couturier, B.S., Soupart, A., Brion, J.P. and Decaux, G. (2017) Osmotic Stress-Induced Defective Glial Proteostasis Contributes to Brain Demyelination af-ter Hyponatremia Treatment. Journal of the American Society of Nephrology, 28, 1802-1813. <br>https://doi.org/10.1681/ASN.2016050509Thomsen, R.W., Nicolaisen, S.K., Hasvold, P., et al. (2018) Ele-vated Potassium Levels in Patients with Chronic Kidney Disease: Occurrence, Risk Factors and Clinical Outcomes—A Danish Population-Based Cohort Study. Nephrology Dialysis Transplantation, 33, 1610. <br>https://doi.org/10.1093/ndt/gfx312Luo, J., Brunelli, S.M., Jensen, D.E. and Yang, A. (2016) Association between Serum Potassium and Outcomes in Patients with Reduced Kidney Function. Clinical Journal of the American Society of Nephrology, 11, 90-100.
<br>https://doi.org/10.2215/CJN.01730215Petramala, L., Savoriti, C., Zinnamosca, L., Marinelli, C., Sette-vendemmie, A., Calvieri, C., Catani, M. and Letizia, C. (2013) Primary Aldosteronism with Concurrent Primary Hy-perparathyroidism in a Patient with Arrhythmic Disorders. Internal Medicine, 52, 2071-2075. <br>https://doi.org/10.2169/internalmedicine.52.8794Ruljancic, N., Popovic-Grle, S., Rumenjak, V., Sokolic, B., Malic, A., Mihanovic, M., et al. (2007) COPD: Magnesium in the Plasma and Polymorphonuclear Cells of Patients dur-ing a Stable Phase. COPD, 4, 41-47.
<br>https://doi.org/10.1080/15412550601169513Siafakas, N.M. and Tzortzaki, E.G. (2002) Few Smokers De-velop COPD. Why? Respiratory Medicine, 96, 615-624.
<br>https://doi.org/10.1053/rmed.2002.1318