心肌纤维化是老化心脏的重要特征,其严重程度随着年龄增长逐渐加重,可损害心脏结构。在增龄过程中,不同性别的心肌纤维化严重程度及纤维化类型不同。老年男性总心肌纤维化程度(替代性纤维化 + 反应性纤维化)更高,但以哪一类型为主尚不清楚,而老年女性以反应性纤维化为主,这可能与雌激素、雄激素对心肌纤维化发生发展的影响有关。因此,探索性别影响增龄所致心肌纤维化的因素,为将来针对老年人提供更多的抗纤维化治疗靶点,进而改善老年人生活质量。
Myocardial fibrosis is an important feature of the aging heart, and its increasing severity with age can damage the heart structure. During aging, the severity of myocardial fibrosis and the type of fi-brosis are different. The degree of total myocardial fibrosis (alternative fibrosis + reactive fibrosis) is higher in older men, but it is unclear which type is predominant, while older women are mainly reactive fibrosis, which may be related to the influence of estrogen and androgen on the occurrence and development of myocardial fibrosis. Therefore, the factors affecting myocardial fibrosis caused by gender should be explored to provide more antifibrotic therapeutic targets for the elderly, and then improve the quality of life in the elderly.
Myocardial fibrosis is an important feature of the aging heart, and its increasing severity with age can damage the heart structure. During aging, the severity of myocardial fibrosis and the type of fibrosis are different. The degree of total myocardial fibrosis (alternative fibrosis + reactive fibrosis) is higher in older men, but it is unclear which type is predominant, while older women are mainly reactive fibrosis, which may be related to the influence of estrogen and androgen on the occurrence and development of myocardial fibrosis. Therefore, the factors affecting myocardial fibrosis caused by gender should be explored to provide more antifibrotic therapeutic targets for the elderly, and then improve the quality of life in the elderly.
王云会,邓 玮. 性别与增龄所致心肌纤维化Gender and Aging Lead to Myocardial Fibrosis[J]. 临床医学进展, 2022, 12(11): 10026-10033. https://doi.org/10.12677/ACM.2022.12111446
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