目的:本研究探讨饮用富氢水对肾肿瘤患者术后肾功能恢复的临床研究。方法:选择2022年1月至2022年10月在泌尿外科确诊且住院手术治疗的肾肿瘤患者86例,随机区组法1:1分为研究组和对照组。对照组术后第1、3、7和15天检测患者肾功能指标,研究组在此检测基础给与患者富氢水治疗。比较两组患者术后的肾功能变化以及随访6月的肾功能差异等。结果:手术前两组肾功能无统计学差异(P > 0.05)。给与富氢水治疗后,研究组第3、7和15天的肌酐显著低于对照组(P < 0.05)。术后6月的随访发现,两组肾功能有显著性差异(P < 0.05),研究组肌酐明显低于对照组。结论:富氢水能够降低患者术后急性期的肌酐水平,改善肾肿瘤患者术后肾功能的恢复。 Objective: To investigate the clinical effect of drinking hydrogen-rich water on renal function recov-ery in patients with renal tumor after surgery. Methods: From January 2022 to October 2022, 86 patients with renal tumor diagnosed in the department of urology and hospitalized for surgical treatment were selected and divided into study group and control group 1:1 by randomized block method. The renal function indexes of patients in the control group were detected on the 1st, 3rd, 7th and 15th day after surgery, and the patients in the study group were treated with hydrogen- rich water on the basis of this detection. The postoperative changes of renal function and the dif-ference of renal function after 6 months of follow-up were compared between the two groups. Re-sults: There was no significant difference in renal function between the two groups before operation (P > 0.05). After treatment with hydrogen-rich water, the creatinine level of the study group at day 3, 7 and 15 was significantly lower than that of the control group (P < 0.05). At the follow-up 6 months after operation, the renal function of the two groups was significantly different (P < 0.05), and the creatinine of the study group was significantly lower than that of the control group. Conclu-sion: Hydrogen-rich water can reduce the creatinine level and improve the recovery of renal func-tion in patients with renal tumor.
目的:本研究探讨饮用富氢水对肾肿瘤患者术后肾功能恢复的临床研究。方法:选择2022年1月至2022年10月在泌尿外科确诊且住院手术治疗的肾肿瘤患者86例,随机区组法1:1分为研究组和对照组。对照组术后第1、3、7和15天检测患者肾功能指标,研究组在此检测基础给与患者富氢水治疗。比较两组患者术后的肾功能变化以及随访6月的肾功能差异等。结果:手术前两组肾功能无统计学差异(P > 0.05)。给与富氢水治疗后,研究组第3、7和15天的肌酐显著低于对照组(P < 0.05)。术后6月的随访发现,两组肾功能有显著性差异(P < 0.05),研究组肌酐明显低于对照组。结论:富氢水能够降低患者术后急性期的肌酐水平,改善肾肿瘤患者术后肾功能的恢复。
富氢水,肾肿瘤,肾功能,临床研究
Zhong Xue, Cuixing Zhou, Hao Lu, Renfang Xu, Xiaozhou He, Dong Xue*
Urology Department of the Third Affiliated Hospital of Suzhou University, Suzhou Jiangsu
Received: Dec. 12th, 2022; accepted: Jan. 5th, 2023; published: Jan. 13th, 2023
Objective: To investigate the clinical effect of drinking hydrogen-rich water on renal function recovery in patients with renal tumor after surgery. Methods: From January 2022 to October 2022, 86 patients with renal tumor diagnosed in the department of urology and hospitalized for surgical treatment were selected and divided into study group and control group 1:1 by randomized block method. The renal function indexes of patients in the control group were detected on the 1st, 3rd, 7th and 15th day after surgery, and the patients in the study group were treated with hydrogen- rich water on the basis of this detection. The postoperative changes of renal function and the difference of renal function after 6 months of follow-up were compared between the two groups. Results: There was no significant difference in renal function between the two groups before operation (P > 0.05). After treatment with hydrogen-rich water, the creatinine level of the study group at day 3, 7 and 15 was significantly lower than that of the control group (P < 0.05). At the follow-up 6 months after operation, the renal function of the two groups was significantly different (P < 0.05), and the creatinine of the study group was significantly lower than that of the control group. Conclusion: Hydrogen-rich water can reduce the creatinine level and improve the recovery of renal function in patients with renal tumor.
Keywords:Hydrogen-Rich Water, Renal Tumor, Kidney Function, Clinical Research
Copyright © 2023 by author(s) and Hans Publishers Inc.
This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).
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肾癌是泌尿生殖系统常见的恶性肿瘤,对于局限性肾癌,外科手术仍是首选的治疗方案 [
自2007年发现分子氢可通过抗氧化作用有效保护脑缺血再灌注损伤以来,氢气的生物学作用被陆续发现 [
选取2022年1月至2022年10月在常州市第一人民医院泌尿外科行单侧开放或腹腔镜下根治性肾切除术86例,按照随机区组法,1:1分为两组,研究组43例,对照组43例。排除标准:年龄 < 18岁或>80岁,双肾或孤立肾肿瘤,肾肿瘤复发或转移,伴随其他恶性肿瘤,严重肾功能不全或其他脏器功能衰竭。两组患者的基线资料:年龄、性别、术前肾功能指标等方面无统计学差异。见表1。本课题采取回顾性临床研究,研究方案经本院伦理委员会批准,病人患者知情并签署同意书。
基本情况 | 研究组(n = 43) | 对照组(n = 43) | P值 |
---|---|---|---|
年龄 | 63.5 ± 11.2 | 64.6 ± 12.7 | 0.621 |
性别(男%) | 30 (69.7) | 27 (62.8) | 0.413 |
尿素(mmol/L) | 4.9 ± 1.6 | 4.9 ± 1.4 | 0.825 |
肌酐(umol/L) | 76.8 ± 15.7 | 77.9 ± 14.5 | 0.653 |
表1. 入组患者基线特征
富氢水饮用方法:研究组患者在肾肿瘤术通气后,每日饮用2 L富氢水(江苏滕田生物科技有限公司提供高浓度富氢水杯),对照组患者确保每日补充2 L饮用水。研究组富氢水饮用至患者出院。
临床肾功能指标:分别于实验开始前1天,术后第1、3、7和15天,以及术后第6月随访时空腹抽取两组患者的外周静脉血,采用日立7600全自动生化分析仪检测肾功能的尿素、肌酐指标。
使用SPSS 22.0软件进行数据分析,计量资料以 x ¯ ± s表示,组间比较采用成组t检验;计数资料采用例和百分比表示,组间比较采用卡方检验。P < 0.05为差异有统计学意义。
86例患者均完成所有随访。主要肾功能指标:治疗前两组的尿素、肌酐均差异无统计学意义(P > 0.05)。肾肿瘤手术后,第1天两组的尿素、肌酐均升高,两组差异无统计学意义(P > 0.05);第3天两组尿素、肌酐均开始降低,两组差异无统计学意义(P > 0.05);第5天研究组肌酐下降更多,两组肌酐差异有统计学意义(P < 0.05);第7天两组尿素、肌酐差异有统计学意义(P < 0.05);术后6月随访时,两组尿素、肌酐差异有统计学意义(P < 0.05)。见表2、表3。
项目 | 研究组(n = 43) | 对照组(n = 43) | t | P值 |
---|---|---|---|---|
术前1天 | 4.9 ± 1.6 | 4.9 ± 1.4 | 6.78 | 0.825 |
术后1天 | 5.7 ± 1.3 | 5.8 ± 1.5 | 5.42 | 0.521 |
术后3天 | 5.5 ± 1.7 | 5.7 ± 1.2 | 4.21 | 0.364 |
术后5天 | 5.1 ± 1.5 | 5.6 ± 1.4 | 2.67 | 0.165 |
术后7天 | 4.9 ± 1.1 | 5.5 ± 1.6 | 1.42 | 0.03 |
随访6月 | 4.8 ± 1.7 | 5.4 ± 1.2 | 0.87 | 0.01 |
表2. 两组尿素在治疗前后的比较( x ¯ ± s)
项目 | 研究组(n = 43) | 对照组(n = 43) | t | P值 |
---|---|---|---|---|
术前1天 | 76.8 ± 15.7 | 77.9 ± 14.5 | 4.28 | 0.653 |
术后1天 | 115.2 ± 22.3 | 117.2 ± 24.2 | 4.97 | 0.475 |
术后3天 | 110.3 ± 19.5 | 112.2 ± 22.7 | 3.92 | 0.285 |
术后5天 | 98.3 ± 19.8 | 108.3 ± 21.6 | 2.15 | 0.036 |
术后7天 | 85.2 ± 20.6 | 99.6 ± 23.3 | 0.87 | 0.01 |
随访6月 | 75.6 ± 18.6 | 87.3 ± 24.2 | 0.63 | 0.01 |
表3. 两组肌酐在治疗前后的比较( x ¯ ± s)
肾细胞癌是来源于肾小管上皮的恶性肿瘤,是泌尿系统常见的肿瘤之一,目前根治性肾切除术仍是肾癌治疗的主要方案 [
根治性肾切除术是肾癌患者术后急性肾损伤及发生远期慢性肾衰竭的独立危险因素 [
根治性肾切除术后因肾脏功能的损失,往往会有慢性肾功能不全的风险,需要日常的随访和观察。最近研究表明,在肾脏疾病中klotho的表达被显著抑制,进而导致肾脏纤维化。腹腔注射富氢水保留了klotho的表达并激活肾脏中的自噬而发挥抑制急性肾损伤后肾脏纤维化的作用 [
综上所述,本研究结果发现富氢水治疗能改善肾肿瘤患者的术后恢复,降低尿素、肌酐的水平,保护了患者的肾功能,延缓肾功能的减退,临床应用于肾肿瘤患者的治疗,有助于患者生存质量的提高。
薛 钟,周萃星,陆 皓,徐仁芳,何小舟,薛 冬. 富氢水对肾肿瘤患者术后肾功能恢复的临床研究进展Clinical Research Progress of Hydrogen-Rich Water on Renal Function Recovery in Patients with Renal Tumor after Surgery[J]. 临床医学进展, 2023, 13(01): 344-348. https://doi.org/10.12677/ACM.2023.131052